Table 5 Representation of spliced genes among COPs, and correlation analysis for transcript modifications among these genes

COP genes show a strong positive bias for splicing

Total

30,624

1,912

Spliced

21,157 (69.1%)

1,723 (90.1%)

4.7e-113

Spliced COP genes show a positive bias for alternative splicing

Spliced

21,157

1,723

Alternatively spliced

2,331 (11.0%)

268 (15.6%)

1.3e-9

Alternatively spliced COP genes do not show a significant bias for alternative splicing at the last intron, TSS variation or polyadenylation site variation

Alternatively spliced

2,331

268

Last intron alternative splicing

1,662 (71.3%)

195 (72.8%)

0.31

TSS variation

1,424 (61%)

158 (59.0%)

0.24

Polyadenylation site variation

1,019 (43.7%)

107 (39.9%)

0.10