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Table 3 Overview of mechanisms of metabolic flexibility that confer robustness to central metabolic deletions

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Duplicate gene* Duplicate gene and alternative pathway Alternative pathway None
ADH3, ALD5, DAL7, GPD1,ICL1, IDP1, IDP2, MDH2, MDH3, MLS1, PGM1, PGM2, SDH1, SER33,SOL1, SOL2, SOL3, SOL4, TAL1, YGR043c ADH1, ALD6, COX5A,MDH1 FUM1, GLY1, LSC1, MAE1, MDH1, OAC1, PCK1, PDA1, RPE1, ZWF1 CTP1, GCV2, GND1§, GND2, SFC1
  1. *Wild-type-like flux distribution. Altered flux distribution, but some residual flux through the reaction was observed. Altered flux distribution, but no residual flux through the reaction was observed. § Lethal, probably because of a non-stoichiometric effect.