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Table 3 Overview of mechanisms of metabolic flexibility that confer robustness to central metabolic deletions

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Duplicate gene*

Duplicate gene and alternative pathway†

Alternative pathway‡

None

ADH3, ALD5, DAL7, GPD1,ICL1, IDP1, IDP2, MDH2, MDH3, MLS1, PGM1, PGM2, SDH1, SER33,SOL1, SOL2, SOL3, SOL4, TAL1, YGR043c

ADH1, ALD6, COX5A,MDH1

FUM1, GLY1, LSC1, MAE1, MDH1, OAC1, PCK1, PDA1, RPE1, ZWF1

CTP1, GCV2, GND1§, GND2, SFC1

  1. *Wild-type-like flux distribution. †Altered flux distribution, but some residual flux through the reaction was observed. ‡Altered flux distribution, but no residual flux through the reaction was observed. § Lethal, probably because of a non-stoichiometric effect.
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Genome Biology

ISSN: 1474-760X

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