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Table 2 Overview of mutants with a fitness defect of at least 20% or altered flux distribution

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Mutants

Fitness defect in YPD

Fitness defect in MM

Altered intracellular flux distribution*

Total number of mutants

3 of 38

 

12 (+1) of 38

 

11 of 38

 

Singleton genes

fum1

gly1

fum1

pda1

fum1

pda1

   

gly1

rpe1

lsc1

rpe1

   

oac1

zwf1

mae1

zwf1

     

oac1

 

Duplicate genes

adh1

 

adh1

sdh1

adh1

cox5A

   

ald6

sol3

ald6

mdh1

   

cox5A

(gnd1)

  
   

mdh1

   
  1. *See Figures 5 and 6. Lethal mutations are given in parentheses.