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Table 2 Overview of mutants with a fitness defect of at least 20% or altered flux distribution

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Mutants Fitness defect in YPD Fitness defect in MM Altered intracellular flux distribution*
Total number of mutants 3 of 38   12 (+1) of 38   11 of 38  
Singleton genes fum1 gly1 fum1 pda1 fum1 pda1
    gly1 rpe1 lsc1 rpe1
    oac1 zwf1 mae1 zwf1
      oac1  
Duplicate genes adh1   adh1 sdh1 adh1 cox5A
    ald6 sol3 ald6 mdh1
    cox5A (gnd1)   
    mdh1    
  1. *See Figures 5 and 6. Lethal mutations are given in parentheses.