Skip to main content

Table 1 Fitness of mutants with deletions in flexible central metabolic reactions

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

  Physiological fitness* Competitive fitness   Physiological fitness Competitive fitness
Mutants MM YPD YPD Mutants MM YPD YPD
Reference strain 1 1 1     
adh1/YOL086C 0.47 0.57 0.79 mdh2/YOL126C 0.89 0.98 1.01
adh3/YMR083W 0.92 0.87 0.98 mdh3/YDL078C 1.00 0.96 1.01
ald5/YER073W 1.02 0.94 1 mls1/YNL117W 1 0.98 1
ald6/YPL061W 0.34 0.87 0.9 oac1/YKL120W 0.71 0.94 1.01
cox5A/YNL052W 0.63 0.91 1 pck1/YKR097W 1 0.96 1
ctp1/YBR291C 0.91 1 0.97 pda1/YER178W 0.41 0.98 1
dal7/YIR031C 0.94 0.85 1 pgm1/YKL127W 0.82 0.94 1
fum1/YPL262W 0.52 0.62 0.93 pgm2/YMR105C 0.90 1 1
gnd1/YHR183W 0 0.87 1.01 rpe1/YJL121C 0.33 0.94 0.88
gnd2/YGR256W 0.83 0.98 1 sdh1/YKL148C 0.72 0.94 1
gcv2/YMR189W 0.92 0.94 1 ser33/YIL074C 0.92 0.94 1.01
gly1/YEL046C 0.79 0.74 0.87 sfc1/YJR095W 0.84 0.96 1.01
gpd1/YDL022W 1 0.98 0.84 sol1/YNR034W 0.91 1 1.02
icl1/YER065C 1 1 1 sol2/YCRX13W 0.99 0.98 1
idp1/YDL066W 0.92 0.94 1.03 sol3/ YHR163W 0.71 0.94 1
idp2/YLR174W 0.86 0.96 0.95 sol4/ YGR248W 0.95 0.91 1.01
lsc1/YOR142W 1.05 0.93 1 tal1/ YLR354C 0.89 0.94 1
mae1/YKL029C 1.01 0.96 1 YGR043C 0.92 0.87 1.02
mdh1/YKL085W 0.72 0.91 1 zwf1/YNL241C 0.38 0.96 ND
  1. *Physiological fitness is defined as the maximal specific growth rate of a mutant normalized to the reference strain CEN.PK 113-7D ho :: kanMX4. The average from triplicate experiments is shown. The standard deviation was generally below 0.05. From Steinmetz et al. [20]. ND, not detected.