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Table 2 Definitions and examples of class-level relations

From: Relations in biomedical ontologies

Relations and relata

Definitions

Examples

C is_a C1; Cs and C1s are continuants

Every C at any time is at the same time a C1

myelin is_a lipoprotein

  

serotonin is_a biogenic amine

  

mitochondrion is_a membranous cytoplasmic organelle

  

protein kinase is_a kinase

  

DNA is_a nucleic acid

P is_a P1; Ps and P1s are processes

Every P is a P1

endomitosos is_a DNA replication

  

catabolic process is_a metabolic process

  

photosynthesis is_a physiological process

  

gonad development is_a organogenesis

  

intracellular signaling cascade is_a signal transduction

C part_of C1; Cs and C1s are continuants

Every C at any time is part of some C1 at the same time

mitochondrial matrix part_of mitochondrion

  

microtubule part_of cytoskeleton

  

nuclear pore complex part_of nuclear membrane

  

nucleoplasm part_of nucleus

  

promotor part_of gene

P part_of P1; Ps and P1s are processes

Every P is part of some P1

gastrulation part_of embryonic development

  

cystoblast cell division part_of germ cell development

  

cytokinesis part_of cell proliferation

  

transcription part_of gene expression

  

neurotransmitter release part_of synaptic transmission

C located_in C1; Cs and C1s are continuants

Every C at any given time occupies a spatial region which is part of the region occupied by some C1 at the same time

66s pre-ribosome located_in nucleolus

  

intron located_in gene

  

nucleolus located_in nucleus

  

membrane receptor located_in cell membrane

  

chlorophyll located_in thylakoid

C contained_in C1; Cs are material continuants, C1s are immaterial continuants (holes, cavities)

Every C at any given time is located in but shares no parts in common with some C1 at the same time

thoracic aorta contained_in posterior mediastinal cavity

  

cytosol contained_in cell compartment space

  

thylakoid contained_in chloroplast membrane

  

synaptic vesicle contained_in neuron

C adjacent_to C1; Cs and C1s are continuants

Every C at any time is proximate to some C1 at the same time

Golgi apparatus adjacent_to endoplasmic reticulum

  

intron adjacent_to exon

  

cell wall adjacent_to cytoplasm

  

periplasm adjacent_to plasma membrane

  

presynaptic membrane adjacent_to synaptic cleft

C transformation_of C1; Cs and C1s are material continuants

Every C at any time is identical with some C1 at some earlier time

facultative heterochromatin transformation_of euchromatin

  

mature mRNA transformation_of pre-mRNA

  

hemosiderin transformation_of hemoglobin

  

red blood cell transformation_of reticulocyte

  

fetus transformation_of embryo

C derives_from C1; Cs and C1s are material continuants

Every C is such that in the first moment of its existence it occupies a spatial region which overlaps the spatial region occupied by some C1 in the last moment of its existence

plasma cell derives_from B lymphocyte

  

fatty acid derives_from triglyceride

  

triple oxygen molecule derives_from oxygen molecule

  

Barr body derives_from X-chromosome

  

mammal derives_from gamete

P preceded_by P1; Ps and P1s are processes

Every P is such that there is some earlier P1

translation preceded_by transcription

  

meiosis preceded_by chromosome duplication

  

cytokinesis preceded_by DNA replication

  

apoptotic cell death preceded_by nuclear chromatin degradation

  

digestion preceded_by ingestion

P has_participant C; Ps are processes, Cs are continuants

Every P involves some C as participant

mitochondrial acetylCoA formation has_participant pyruvate dehydrogenase complex

  

translation has_participant amino acid

  

photosynthesis has_participant chlorophyll

  

apoptosis has_participant cell

  

cell division has_participant chromosome

P has_agent C; Ps are processes, Cs are material continuants

Every P involves some C as agent (the C is involved in and is causally responsible for the P)

gene expression has_agent RNA polymerase

  

signal transduction has_agent receptor

  

pathogenesis has_agent pathogen

  

transcription has_agent RNA polymerase

  

translation has_agent ribosome