|
Cluster
|
Number of genes*
|
Dependence of gene induction†
|
Binding-site enrichment‡
|
|---|
| | |
ATM
|
Rel-A (NFκB)
|
p53
|
NFκB (M00054)
|
ATF2 (M00179)
|
|---|
|
1
|
26
|
++
|
++
|
+
|
9.7 (6.0 × 10-12)
|
-
|
|
3
|
46
|
++
|
-
|
++
|
-
|
2.9 (2.7 × 10-5)
|
|
4
|
12
|
+
|
-
|
++
|
-
|
6.6 (3.6 × 10-6)
|
- *Number of genes with promoter sequence data. †Strong attenuation in induction of the cluster's genes in the respective cells is denoted by ++; partial attenuation is denoted by +; and no attenuation by -. ‡The ratio between transcription-factor hit prevalence in the cluster and in the background sets of promoters, and its p-value (accession numbers for transcription-factor binding site models are from TRANSFAC DB).
