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Table 4 Candidate QTLs for starvation resistance

From: Quantitative genomics of starvation stress resistance in Drosophila

Probe set

Significant*

Gene

Location

Molecular function

Biological process

Cellular location

151378

S, L, r

mitochondrial ribosomal protein L33

4B6

Structural constituent of ribosome

Protein biosynthesis

Mitochondrial large ribosomal subunit

151504

L

no receptor potential A

4C1

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; phospholipase C

Olfaction; response to abiotic stimulus

inD signaling complex; membrane fraction; rhabdomere

153437

S, T, L, r

yippee interacting protein 2

30E4

Acetyl-CoA C-acyltransferase

Fatty acid beta oxidation

Mitochondrion

146142

S, T, L, r

Selenophosphate synthetase 2

31D9

Selenide, water dikinase; purine nucleotide binding

Selenocysteine biosynthesis

 

143984

S, T, S × T, L, L × S

Accessory gland-specific peptide 32CD

32D1

Hormone

Negative regulation of female receptivity, post-mating

Extracellular

141745

S, L, L × S, L × T, r

Phosphoethanolamine cytidylyltransferase

34A9

Ethanolamine-phosphate cytidylyltransferase

ethanolamine and derivative metabolism; phospholipid metabolism

 

146347

S, L, L × S, L × T, L × S × T

centaurin gamma 1A

34D6-E2

ARF GTPase activator

G-protein-coupled receptor protein signaling pathway; small GTPase mediated signal transduction

Nucleus

153741

L × T

centaurin gamma 1A

34D6-E2

ARF GTPase activator

G-protein coupled receptor protein signaling pathway; small GTPase mediated signal transduction

Nucleus

143402

S, L, L × S, r

vasa

35C1

RNA helicase activity; nucleic acid binding; ATP dependent helicase

Dorsal appendage formation; oogenesis; pole plasm RNA localization; pole plasm assembly

Polar granule

152721

T, L, L × T, r

Imaginal disc growth factor 1

36A1

Imaginal disc growth factor activity; NOT chitinase activity; hydrolase activity, hydrolyzing N-glycosyl compounds

Cell-cell signaling;signal transduction

Extracellular

154661

S, L

midway

36B1-2

Sterol O-acetyltransferase; diacylglycerol O-actyltransferase

Cholesterol metabolism; triacylglycerol biosynthesis

 

152756

S, L, r

Arrestin 1

36D3

Metarhodopsin binding

G-protein coupled receptor protein signaling pathway; deactivation of rhodopsin mediated signaling; endocytosis; intracellular protein transport; metarhodopsin inactivation

Membrane fraction; rhabdomere

143876

S, L

Galactose-specific C-type lectin

37D6

Galactose binding; sugar binding; receptor

Defense response

 

146555

S, T, S × T, L, L× S

Serine protease inhibitor 3

38F2

Serine-type endopeptidase inhibitor

Proteolysis and peptidolysis

 

146592

S, T, S × T, L× T, L× S× T

no mechanoreceptor potential B

39E2

 

NOT flagellum biogenesis; perception of sound; sensory cilium biogenesis

 

143709

S, T, L, r

Troponin C at 41C

41E5

Calcium ion binding; calmodulin binding

Calcium-mediated signaling; muscle contraction

 

143127

S, T, L, L × T

Cytochrome P450-6a2

42C8-9

Electron transporter activity; oxidoreductase

Response to insecticide; steroid metabolism

Membrane; microsome

146718

S, T, L × T

Tetraspanin 42Er

42F1

Receptor signaling protein

Ectoderm development; neurogenesis; transmission of nerve impulse

Integral to membrane

142222

T, L, L × T

Cytochrome P450-9b2

42F3

Electron transporter activity; oxidoreductase

 

Membrane; microsome

143830

S, L

Calcineurin B2

43E16

Calmodulin binding; calcium-dependent protein serine/threonine phosphatase, regulator; calcium ion binding

Calcium-mediated signaling; cell homeostasis

Calcineurin complex

141501

S, T, L, r

Proteasome alpha6 subunit

43E18

Proteasome endopeptidase

Proteolysis and peptidolysis

20S core proteasome complex

143303

S, T, L, r

photorepair

43E18

Deoxyribodipyrimidine photolyase; nucleic acid binding

DNA repair

 

146780

S, L × T, L × S × T, r

Sep5

43F8

Structural constituent of cytoskeleton; small monomeric GTPase

Cytokinesis; mitosis

Septin ring

143780

L, L × S

Cytochrome P450-4e1

44D1

Electron transporter activity; oxidoreductase

 

Membrane; microsome

152113

S, T, L × S, r

anachronism

45A1

 

Suppression of neuroblast proliferation

Extracellular

143554

S, L

trp-like

46B2

Calcium channel; calmodulin binding; light-activated voltage-gated calcium channel; store-operated calcium channel

Calcium ion transport

Plasma membrane; rhabdomere

146946

S, T, L × T, r

Peroxiredoxin 2540

47A7

Antioxidant; peroxidase; non-selenium glutathione peroxidase

Defense response; oxygen and reactive oxygen species metabolism

 

143603

T, L

gammaTrypsin

47F4

NOT serine-type endopeptidase

Proteolysis and peptidolysis

Extracellular

143602

T, L

betaTrypsin

47F4

Trypsin

Proteolysis and peptidolysis

Extracellular

143604

T, L

gammaTrypsin

47F4

NOT serine-type endopeptidase

Proteolysis and peptidolysis

Extracellular

143624

T, L × T

epsilonTrypsin

47F4

Trypsin

Proteolysis and peptidolysis

Extracellular

153279

S, T, L, r

Translocon-associated protein d

47F7

Signal sequence receptor

Protein-ER retention

Signal sequence receptor complex; translocon

141563

L

acyl-Coenzyme A oxidase at 57D proximal

57E1

Acyl-CoA oxidase; palmitoyl-CoA oxidase

Fatty acid beta-oxidation

Peroxisome

151902

S, T, L, r

jitterbug

59A3

Actin binding; structural constituent of cytoskeleton

Cytoskeleton organization and biogenesis

 

154177

S, L, L × S, r

Cyclin B

59B2

Cyclin-dependent protein kinase, regulator

Cytokinesis; mitotic anaphase B; mitotic chromosome movement

Nuclear cyclin-dependent protein kinase holoenzyme complex; pole plasm

143203

S, T, L, r

inactivation no afterpotential D

59B3

Structural molecule; calmodulin binding; myosin binding; receptor signaling complex scaffold

Cell surface receptor linked signal transduction; phototransduction; protein targeting

inaD signaling complex; rhabdomere

151517

L

Phosphotidylinositol 3 kinase 59F

59E4-F1

Phosphatidylinositol 3-kinase; phosphoinositide 3-kinase

Endocytosis; phosphoinositide phosphorylation; protein targeting

Phosphoinositide 3-kinase complex, class III

151830

S, T, L, L × T, r

lethal (2) essential for life

59F6

Heat shock protein

Defense response; protein folding; response to stress

 

144140

T, L, r

Mitochondrial phosphate carrier protein

70E1

Phosphate transporter; carrier

Phosphate metabolism; phosphate transport

Mitochondrial inner membrane

151748

L, L × T, r

Cyclic-AMP response element binding protein A

71E1

DNA binding; RNA polymerase II transcription factor; transcription factor

Salivary gland morphogenesis; transcription from Pol II promoter

Nucleus

153226

S, T, L

Argonaute 2

71E1

Translation initiation factor; protein binding

RNA interference; translational initiation

RNA-induced silencing complex

  1. *Significant (P < 0.001) for the main effects of Sex (S), treatment (T), line (L) and their interactions from ANOVA of transcript abundance; significant (P < 0.05) correlation (r) between starvation half-life and transcript abundance.