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Table 2 Functional analysis of gene expression differences between autopsy and resection samples

From: Systematic analysis of gene expression in human brains before and after death

GO ID Term Expressed genes Significant differences* Change p value Conservation p value
GO:0006412 Protein biosynthesis 462 101 (37/64) 0.001 0.999
GO:0006512 Ubiquitin cycle 473 119 (86/33) 0.000 1.000
GO:0016567 Protein ubiquitination 256 60 (41/19) 0.002 0.999
GO:0006511 Ubiquitin-dependent protein catabolism 104 36 (23/13) 0.000 1.000
GO:0006396 RNA processing 341 118 (64/54) 0.011 0.995
GO:0006397 mRNA processing 217 74 (44/30) 0.002 0.999
GO:0008380 RNA splicing 183 67 (39/28) 0.000 1.000
GO:0006281 DNA repair 168 40 (23/17) 0.009 0.995
GO:0000398 Nuclear mRNA splicing, via spliceosome 155 54 (30/24) 0.000 1.000
GO:0006364 rRNA processing 32 16 (3/13) 0.000 1.000
GO:0006996 Organelle organization and biogenesis 367 83 (30/53) 0.048 0.964
GO:0006886 Intracellular protein transport 263 62 (32/30) 0.002 0.999
GO:0008624 Induction of apoptosis by extracellular signals 28 13 (2/11) 0.000 1.000
GO:0006120 Electron transport, NADH to ubiquinone 24 10 (3/7) 0.003 0.999
GO:0048247 Lymphocyte chemotaxis 3 3 (0/3) 0.004 1.000
GO:0007242 Intracellular signaling cascade 879 105 0.989 0.016
GO:0007186 GPCR protein signaling pathway 448 39 1.000 0.000
GO:0007267 Cell-cell signaling 417 39 0.998 0.003
GO:0007243 Protein kinase cascade 231 24 0.997 0.005
GO:0045860 Positive regulation of protein kinase activity 41 1 0.999 0.006
GO:0007268 Synaptic transmission 203 18 0.999 0.001
GO:0007187 G-protein signaling (cyclic nucleotide second messenger) 73 4 0.999 0.004
GO:0050896 Response to stimulus 1,326 179 0.975 0.035
GO:0009605 Response to external stimulus 781 90 0.972 0.037
GO:0009617 Response to bacteria 37 0 1.000 0.001
GO:0007601 Visual perception 126 9 0.999 0.002
GO:0007606 Sensory perception of chemical stimulus 55 2 0.999 0.003
GO:0007275 Development 1,412 174 0.992 0.011
GO:0009887 Organogenesis 770 89 0.997 0.004
GO:0007417 Central nervous system development 92 6 0.999 0.004
GO:0008544 Epidermis development 39 1 0.999 0.008
GO:0050875 Cellular physiological process 3,372 515 1.000 0.000
GO:0050874 Organismal physiological process 1,200 138 0.997 0.004
GO:0006813 Potassium ion transport 139 3 1.000 0.000
GO:0030003 Cation homeostasis 52 1 1.000 0.001
  1. *Numbers in parenthesis correspond to the number of up- and down-regulated genes in the autopsy samples. Bold font indicates Gene Ontology (GO) groups with significant excess of up- or down-regulated genes (see Materials and methods).