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Table 3 Gene Ontology categories correlating in six comparisons of senescence and mouse aging data sets

From: The expression signature of in vitro senescence resembles mouse but not human aging

Gene Ontology category

Human senescence

Mouse senescence

 

Aging mouse cerebellum

Aging mouse neocortex

Aging mouse heart

Aging mouse cerebellum

Aging mouse neocortex

Aging mouse heart

ATP biosynthesis

GO:0006754

P = 0.00648

-

P = 0.019

P = 0.00262

P = 0.0135

P = 0.0222

Hydrogen-exporting

ATPase activity

GO:0008553

P = 0.0284

-

P = 0.00701

P = 0.00293

-

P = 0.00394

Pre-mRNA splicing factor activity

GO:0008248

-

-

P = 0.0229

P = 0.00199

P = 0.00533

P = 0.000848

Hydrogen ion transporter activity

GO:0015078

P = 0.0134

-

P = 0.00532

P = 0.000814

-

P = 0.023

Mitotic sister chromatid segregation

GO:0000070

-

-

-

P = 0.000947

P = 0.0462

P = 0.0103

Nuclear mRNA splicing via spliceosome

GO:0000398

-

-

P = 0.022

P < 0.000001

-

P = 0.000918

Spliceosome complex

GO:0005681

-

-

-

P = 0.000124

P = 0.00589

P = 0.0199

Lysosome

GO:0005764

-

-

P = 0.00545

P = 0.00641

-

P = 0.0449

Protein folding

GO:0006457

P = 0.0469

-

-

P = 3.47e-06

P = 1.25e-05

-

Regulation of cell cycle

GO:0000074

-

-

-

P = 1.74e-05

P = 0.00372

P = 0.0083

Metalloendopeptidase activity

GO:0004222

P = 0.0012

P = 0.0115

-

-

-

P = 0.00277

Nucleus

GO:0005634

-

-

-

P = 0.000188

P = 0.00143

P < 0.000001

Chaperonin-containing

T-complex

GO:0005832

P = 0.0447

-

-

P < 0.000001

P < 0.000001

-

Negative regulation of cell proliferation

GO:0008285

-

-

P = 0.00615

P = 0.00636

-

P = 0.00246

Proton transport

GO:0015992

-

-

P = 0.0126

P = 0.00713

-

P = 0.0042

Endoplasmic reticulum

GO:0005783

-

P = 0.0402

-

-

P = 0.0372

P = 0.0272

Cytoskeleton

GO:0005856

-

-

-

P = 0.0347

P = 0.0308

P = 0.0251

RNA binding

GO:0003723

-

-

-

P = 0.00305

P = 0.0112

P = 4.89e-05

Cytoplasm

GO:0005737

-

-

-

P = 0.0137

P = 0.00965

P = 5.49e-05

Respiratory gaseous exchange

GO:0007585

-

-

-

P = 6.25e-05

P = 8.77e-06

P < 0.000001

  1. Gene Ontology categories correlating in six comparisons of senescence (human and mouse) and mouse aging datasets. Shown are P values for partial summations of the Pearson correlation for individual Gene Ontology categories. The P values were calculated using Monte Carlo simulations as a reference. Only categories beyond the third branch in the Gene Ontology tree, appearing in more than two of six comparisons, are included. - signifies p > 0.05.
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Genome Biology

ISSN: 1474-760X

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