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Table 3 Significance of occurrence of predicted SREBP-1 binding sites in the promoters of co-expressed genes identified by clustering

From: Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

SREBP-1 Putative target genes Genes in cluster Against total PromoSer database Against total of all clusters
    CS FE CS FE
Cluster 1 4 10 0.5000 0.7051 0.5339 0.7644
Cluster 2 11 27 0.5448 0.6892 0.6475 0.7812
Cluster 3 5 16 0.7076 0.8575 0.7697 0.8987
Cluster 4 9 12 0.0290 0.0289 0.0494 0.0484
Cluster 5 16 45 0.7787 0.8570 0.8568 0.9171
Cluster 6 10 20 0.1553 0.1554 0.2278 0.2277
Cluster 7 5 10 0.5000 0.5677 0.5000 0.6423
Cluster 8 31 66 0.2837 0.2827 0.4719 0.4711
Cluster 9 12 42 0.9025 0.9454 0.9414 0.9708
Cluster 10 22 41 0.1635 0.1635 0.2881 0.2877
Cluster 11 8 15 0.3230 0.3204 0.4057 0.4041
Cluster 12 25 45 0.0398 0.0404 0.1014 0.1014
PromoSer 5,456 12,493     
  1. Probabilities for over-representation (<0.05) of genes having a predicted SREBP-1 site relative to all unique regulated genes of PromoSer and to the total of all clusters. Cluster 4 is the only one with significantly increased occurrence of predicted SREBP-1 binding sites. CS, one-sided χ2 test; FE, one-sided Fisher's exact test; SREBP, sterol-regulatory element binding protein.