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Table 2 Transcription factors that could regulate co-expressed genes in each cluster

From: Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

Binding factors Over-represented cluster CS FE Putative target genes Genes in cluster with promoter in PromoSer database Putative target genes of all clusters
RORα1 Cluster 1 0.0322 0.0203 10 10 240
ATF Cluster 2 0.0466 0.0481 15 27 133
CRE-BP1 Cluster 2 0.0050 0.0050 19 27 153
HLF Cluster 2 0.0436 0.0452 15 27 132
XBP-1 Cluster 2 0.0378 0.0476 4 27 17
AhR Cluster 2 0.0287 0.0446 3 27 9
Tal-1β/E47 Cluster 3 0.0400 0.0427 9 15 123
v-Maf Cluster 4 0.0432 0.0308 2 12 11
SREBP-1 Cluster 4 0.0494 0.0484 9 12 166
Tal-1β/ITF-2 Cluster 5 0.0145 0.0169 19 46 89
Pbx-1 Cluster 5 0.0323 0.0206 45 46 312
NRF-2 Cluster 5 0.0310 0.0252 41 46 270
Sox-5 Cluster 5 - 0.0490 40 46 268
VBP Cluster 5 0.0345 0.0276 42 46 281
NF-κB (p65) Cluster 6 0.0354 0.0333 13 17 182
CCAAT box Cluster 6 0.0458 0.0287 17 17 288
AP-2 Cluster 6 0.0330 0.0268 15 17 226
E4BP4 Cluster 8 0.0230 0.0243 31 69 113
CCAAT Cluster 8 0.0211 0.0304 5 69 7
VBP Cluster 8 0.0242 0.196 62 69 281
GC box Cluster 9 - 0.0450 44 48 289
RREB-1 Cluster 10 0.0388 0.0435 13 42 65
SRF Cluster 10 0.0221 0.0255 16 42 81
GC box Cluster 10 0.0450 0.0366 39 42 289
Poly A downstream element Cluster 11 0.0335 0.0431 5 13 55
E2 Cluster 12 0.0459 - 14 47 65
  1. Probabilities for over-representation (<0.05) of genes having a predicted transcription factor binding site relative to the total of all clusters. CS, one-sided χ2 test; FE, one-sided Fisher's exact test.