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Table 8 Most statistically significantly regulated functional groups in the fetal heart tissues based on their p values from t tests

From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

GO group GO identifier Number of probe sets p value Mean of GO group Mean of non-group members
Mitochondrion GO:0005739 446 6.61E-16 0.04 -0.01
Monovalent inorganic cation transporter activity GO:0015077 86 4.27E-10 0.07 -0.01
Defense response GO:0006952 485 2.29E-08 -0.06 -0.01
NADH dehydrogenase activity GO:0003954 31 5.25E-06 0.07 -0.01
Intracellular transport GO:0046907 428 2.34E-05 0.02 -0.01
Cell-cell signaling GO:0007267 201 1.02E-04 -0.07 -0.01
Mitochondrial inner membrane GO:0005743 74 1.66E-04 0.04 -0.01
Cell surface receptor linked signal transduction GO:0007166 594 1.74E-04 -0.04 -0.01
Integral to plasma membrane GO:0005887 948 1.95E-04 -0.03 -0.01
Extracellular region GO:0005576 215 2.40E-04 -0.06 -0.01
Membrane fusion GO:0006944 14 4.68E-04 0.06 -0.01
DNA metabolism GO:0006259 322 8.13E-04 0.02 -0.01
Regulation of muscle contraction GO:0006937 28 9.33E-04 0.08 -0.01
Single-stranded DNA binding GO:0003697 45 1.38E-03 0.06 -0.01
Electron carrier activity GO:0009055 12 1.41E-03 0.08 -0.01
  1. There were 769 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.50E-05 (assigned by dividing 0.05 by the number of functional groups, 769).