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Table 6 Most statistically significantly regulated functional groups in the fetal cerebellum tissues based on their p values from t tests

From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

GO group GO identifier Number of probe sets p value Mean of GO group Mean of non-group members
Integral to plasma membrane GO:0005887 933 1.26E-11 0.03 0
RNA binding GO:0003723 469 6.31E-11 -0.02 0.01
Structural constituent of ribosome GO:0003735 212 1.12E-08 -0.03 0.01
G-protein coupled receptor activity GO:0004930 212 1.29E-08 0.06 0
Transmission of nerve impulse GO:0019226 170 3.31E-08 0.06 0
Nucleus GO:0005634 2194 3.55E-08 -0.01 0.01
Cell surface receptor linked signal transduction GO:0007166 592 2.24E-07 0.03 0
Ribosome GO:0005840 147 4.68E-07 -0.03 0.01
Defense response GO:0006952 430 1.07E-06 0.04 0
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism GO:0006139 1596 5.37E-06 -0.01 0.01
Neurogenesis GO:0007399 337 9.55E-06 0.04 0
Eukaryotic translation initiation factor 4 complex GO:0008304 13 2.51E-05 -0.05 0.01
RNA metabolism GO:0016070 286 4.57E-05 -0.02 0.01
GABA receptor activity GO:0016917 15 6.46E-05 0.1 0.01
DNA binding GO:0003677 1126 7.24E-05 -0.01 0.01
  1. There were 764 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between TS21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ("non-group members"). After one type of multiple test comparison correction, the cutoff level for statistical significance was 6.54E-05 (assigned by dividing 0.05 by the number of functional groups, 764).