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Table 5 Most statistically significantly regulated functional groups in the fetal cerebrum tissues based on their p values from t tests

From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

GO group GO identifier Number of probe sets p value Mean of GO group Mean of non-group members
Mitochondrion GO:0005739 417 1.41E-14 0.03 0
Monovalent inorganic cation transporter activity GO:0015077 86 3.72E-09 0.05 0
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism GO:0006139 1495 2.00E-07 -0.02 0
Nucleus GO:0005634 2072 5.50E-07 -0.01 0
Nucleic acid binding GO:0003676 485 1.23E-06 -0.02 0
Oxidoreductase activity GO:0016491 299 3.31E-06 0.02 0
NADH dehydrogenase activity GO:0003954 31 3.80E-06 0.06 0
DNA binding GO:0003677 1071 1.35E-05 -0.02 0
Cytochrome-c oxidase activity GO:0004129 25 8.51E-05 0.05 0
RNA binding GO:0003723 466 1.48E-04 -0.02 0
Transcription factor activity GO:0003700 558 2.40E-04 -0.02 0
Amine metabolism GO:0009308 147 3.47E-04 0.03 0
RNA metabolism GO:0016070 273 7.76E-04 -0.02 0
Heterotrimeric G-protein GTPase, alpha-subunit GO:0000263 8 8.51E-04 0.04 0
Helicase activity GO:0004386 27 1.15E-03 -0.05 0
  1. The Gene Ontology (GO) database was used to assign a probe set to a functional group. There were 736 functional groups tested for the cerebrum tissue. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.79E-05 (assigned by dividing 0.05 by the number of functional groups, 736).