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Table 2 Most consistently dysregulated non-chromosome 21 genes based on their p values from ANOVA and after 5% false discovery rate cut-off

From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

Gene name Accession number Chromosome number p value (ANOVA) Cerebrum Cerebellum Astrocyte Heart
     Control TS21 Control TS21 Control TS21 Control TS21
Hypermethylated in cancer 1 (HIC1) NM_006497 17 2.33E-08 6.5 1.9 4.8 3.8 4.6 2.0 41.3 5.8
Myomesin 1 (skelemin) (185 kDa) (MYOM1) NM_003803 18 8.82E-08 37.8 23.3 45.0 52.6 13.6 9.8 930.1 1302.5
Myoglobin (MB) NM_005368 22 1.09E-07 103.5 85.5 90.2 142.8 72.9 61.1 7392.9 12099.8
Calsequestrin 2 (cardiac muscle) (CASQ2) NM_001232 1 1.56E-07 17.7 9.3 14.1 19.5 14.4 14.3 2341.5 3868.7
Ras-related associated with diabetes (RRAD) NM_004165 16 5.06E-06 4.5 4.2 13.3 9.8 45.8 36.6 1907.1 932.0
Troponin I, cardiac (TNNI3) NM_000363 19 5.90E-06 49.0 44.1 44.6 71.2 31.1 25.2 2942.4 4757.2
Insulin-like growth factor binding protein 7 (IGFBP7) NM_001553 4 1.12E-05 223.8 314.7 741.5 519.4 2418.6 4205.6 743.8 1137.2
Actin, alpha 1, skeletal muscle (ACTA1) NM_001100 1 1.20E-05 38.6 38.5 33.7 47.6 55.9 138.1 553.4 2310.0
Calcineurin-binding protein calsarcin-1 (MYOZ2) NM_016599 4 1.22E-05 4.9 6.3 7.6 20.2 4.7 3.0 1742.3 2592.5
Teratocarcinoma-derived growth factor 1 (TDGF1) NM_003212 3 1.95E-05 10.6 11.8 8.2 9.9 31.1 20.6 11.3 187.9
Tenomodulin protein (TNMD) NM_022144 X 2.24E-05 7.2 5.4 10.0 6.4 5.8 4.8 23.6 103.0
Olfactory receptor, family 7, subfamily E, member 12 pseudogene (OR7E12P) AA459867 13 2.51E-05 115.4 88.7 149.1 87.6 144.8 116.1 215.1 58.4
Cardiac troponin T2 (TNNT2) X79857 1 2.56E-05 47.4 39.9 47.4 45.7 44.6 32.6 3710.3 4965.9
A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (ADAMTS8) NM_007037 11 3.21E-05 13.0 11.5 14.6 15.5 15.1 11.4 282.8 154.7
  1. The average expression values are for the probe sets corresponding to the genes (from MAS5 software). TS21, trisomy 21.