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Table 2 20E-induced, EcR-dependent genes

From: The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis

Gene 20E 20E primary EcRi -4 h EcRi 0 h EcRi 4 h Function
Eip74A* 11.0 12.6 -4.9 -4.5 -2.0 Transcription factor
Drosomycin-2 8.1   -4.5 -7.3 -14.5 Defense response
CG14664 4.7   -16.3 -22.9   n/o
GST-E3 3.7 3.2   -1.9   Glutathione transferase
Eip78C* 3.6 3.3 -6.2 -6.9 -1.9 Nuclear receptor
CG10444 3.4   -4.1 -7.1 -2.1 Na+-dependent multivitamin transporter
Punch 3.0 2.4 -3.1 -8.1 -2.2 GTP cyclohydrolase I
CG5171 3.0 2.7 -1.7 -1.5 -3.5 Trehalose-phosphatase
CG2444 3.0   -2.8 -2.4 2.3 n/o
Cyp18a1* 2.9 8.3 -2.3   -1.7 Cytochrome P450
CG5391 2.7   -5.2   3.1 n/o
MESR3 2.6   -1.5 -3.0 -1.6 Ras signaling
CG3714 2.6 2.3   -1.7   Nicotinate phosphoribosyltransferase
rdgBbeta 2.5 4.6   -2.2 -2.4 Phosphatidylinositol transporter
CG8501 2.4    -1.9 -1.8 n/o
l(3)00305 2.4 1.9   -1.6   Serine/threonine kinase
CG11737 2.4   -2.3 -2.0   n/o
Cabut 2.3 5.9 -1.9    Transcription factor
CG17834 2.3 1.6   -2.1 -4.4 n/o
Sox box protein 14 2.3 2.9 -1.5 -1.7   Transcription factor
JIL-1 2.2     -3.0 Protein serine/threonine kinase
CG18212 2.2    -2.1 -1.8 n/o
CG13252 2.2 2.0 -2.1 -2.4 -2.7 n/o
raspberry 2.2 1.7 -1.9 -2.2 -1.8 IMP dehydrogenase
supernumerary limbs 2.2    -3.1 -2.6 Ubiquitin-protein ligase
CG16995 2.1 1.5    -2.8 Defense response
lamina ancestor 2.1 2.9 -1.6 -3.1 -2.4 n/o
CG33090 2.1    -3.9 -1.5 n/o
CG7701 2.1    -1.6   n/o
rhea 2.1    -1.9 -2.2 Actin binding
Ptp52F 2.1 2.2 -2.4 -1.6   Protein tyrosine phosphatase
CG4822 2.1 1.4   -3.1 -2.2 ATPase activity
big brain 2.1     -2.4 Water channel
brain tumor 2.0 2.9   -1.7   Translation regulator
CG11529 2.0   -7.1 -2.2 2.0 Serine-type endopeptidase
CG11509 2.0 1.9    -1.6 n/o
CG3348 2.0 4.5 -3.0 -3.1 -1.7 n/o
CG9989 2.0   -1.5 -2.2 -2.5 n/o
blue cheese 1.9 2.0   -2.0 -1.6 Intracellular protein transport
CG14073 1.9 2.4    -1.5 Ankyrin-like
kruppel homolog 1* 1.9 3.5   -1.8 -2.2 Transcription factor
CRMP 1.8 2.6   -2.3 -3.2 Dihydropyrimidinase
CG9801 1.8 3.1   -4.5 -5.7 n/o
CG8483 1.8 5.4 -3.0 -2.8   Defense response
CG9005 1.8 2.4 -1.8 -1.8 -1.8 Cell adhesion
vrille 1.6 3.5    -1.6 Transcription factor
CG1342 1.6 2.4   -2.6 -8.5 Proteinase inhibitor I4, serpin
DHR3* 1.6 2.3    -2.9 Nuclear receptor
Eip75B* 1.5 2.8 -1.6    Nuclear receptor
hairy   4.4   -1.8 -1.6 Transcription factor
CG9192   3.3    -1.7 n/o
CG5249   3.0    -1.5 Transcription factor
black   2.7 -3.0 -7.0   Glutamate decarboxylase 2
CG2016   2.1 -2.0 -2.0 -2.0 n/o
CG12539   2.1 -1.7   -1.6 Glucose dehydrogenase
CG8788   2.0 -1.5 -2.5 -1.8 n/o
  1. Genes that show at least a twofold induction with either 20E alone (20E), or 20E + cycloheximide (20E primary) are listed in the order of their fold-induction by 20E alone. Downregulation of these genes upon EcR RNAi is shown for each time point, -4, 0, or 4 hours relative to puparium formation. Function is inferred from gene ontology on FlyBase. [40]. Asterisks denote previously identified 20E-regulated genes. n/o, no ontology.