Skip to main content

Table 1 EcRi and 20E microarray gene sets compared to gene sets from published microarray studies

From: The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis

Microarrays EcRi↑ (n = 634) EcRi↓ (n = 924) 20E↑ (n = 411) 20E↓ (n = 68)
A midgut;EcR↑ (n = 371) 19 (5.8E-01) 120 (8.4E-91)* 65 (1.3E-63)* 4 (9.7E-02)
B midgut;EcR↓ (n = 292) 113 (1.2E-176)* 12 (8.2E-02) 3 (5.0E-02) 10 (3.1E-13)*
C Steroid CD↑ (n = 916) 34 (2.1-01) 192 (5.3E-73)* 125 (1.7E-87)* 2 (2.3E-01)
D Steroid CD↓ (n = 931) 53 (8.0E-02) 157 (9.3E-39)* 59 (2.3E-10)* 16 (2.3E-08)
E Starv Sug↑ (n = 718) 120 (3.1E-58)* 87 (1.1E-09) 47 (4.5E-09) 12 (2.9E-06)
F Starv Sug↓ (n = 667) 55 (4.3E-06) 90 (7.7E-13)* 32 (4.9E-03) 10 (1.5E-04)
G Stress↑ (n = 253) 33 (5.5E-11)* 34 (1.1E-05) 12 (8.7E-02) 9 (1.4E-12)*
H Stress↓ (n = 310) 87 (4.7E-90)* 25 (3.0E-01) 9 (9.7E-01) 3 (2.2E-01)
I Immune↑ (n = 221) 56 (1.1E-50)* 29 (8.8E-05) 14 (2.6E-03) 13 (3.5E-31)*
J Immune↓ (n = 148) 40 (7.5E-40)* 17 (1.7E-02) 4 (8.6E-01) 3 (6.8E-03)
  1. This table depicts a comparison of EcRi (columns 1 and 2) and 20E-final (columns 3 and 4) microarray data with five other gene sets: rows A and B, EcR-dependent genes expressed in the larval midgut [20]; rows C and D, cell death genes expressed in the larval salivary gland [37]; rows E and F, genes that change expression in response to starvation or a sugar diet [45]; rows G and H, genes that change expression in response to either paraquot, tunicamycin, or H2O2 [43]; and rows I and J, genes that change expression in response to bacterial insult [44]. Each gene set is divided into upregulated or downregulated genes as represented by the arrows, with the number of genes in each dataset represented by '(n =)'. The first number in each cell represents the number of overlapping genes between the two datasets being compared. The numbers within the parentheses in each cell represent a p value based on the χ2 test that accounts for the differences between the observed and expected numbers. Correlations discussed in the text are marked with an asterisk (all those showing a p value ≤ E-10).