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Table 1 EcRi and 20E microarray gene sets compared to gene sets from published microarray studies

From: The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis

Microarrays

EcRi↑ (n = 634)

EcRi↓ (n = 924)

20E↑ (n = 411)

20E↓ (n = 68)

A

midgut;EcR↑ (n = 371)

19 (5.8E-01)

120 (8.4E-91)*

65 (1.3E-63)*

4 (9.7E-02)

B

midgut;EcR↓ (n = 292)

113 (1.2E-176)*

12 (8.2E-02)

3 (5.0E-02)

10 (3.1E-13)*

C

Steroid CD↑ (n = 916)

34 (2.1-01)

192 (5.3E-73)*

125 (1.7E-87)*

2 (2.3E-01)

D

Steroid CD↓ (n = 931)

53 (8.0E-02)

157 (9.3E-39)*

59 (2.3E-10)*

16 (2.3E-08)

E

Starv Sug↑ (n = 718)

120 (3.1E-58)*

87 (1.1E-09)

47 (4.5E-09)

12 (2.9E-06)

F

Starv Sug↓ (n = 667)

55 (4.3E-06)

90 (7.7E-13)*

32 (4.9E-03)

10 (1.5E-04)

G

Stress↑ (n = 253)

33 (5.5E-11)*

34 (1.1E-05)

12 (8.7E-02)

9 (1.4E-12)*

H

Stress↓ (n = 310)

87 (4.7E-90)*

25 (3.0E-01)

9 (9.7E-01)

3 (2.2E-01)

I

Immune↑ (n = 221)

56 (1.1E-50)*

29 (8.8E-05)

14 (2.6E-03)

13 (3.5E-31)*

J

Immune↓ (n = 148)

40 (7.5E-40)*

17 (1.7E-02)

4 (8.6E-01)

3 (6.8E-03)

  1. This table depicts a comparison of EcRi (columns 1 and 2) and 20E-final (columns 3 and 4) microarray data with five other gene sets: rows A and B, EcR-dependent genes expressed in the larval midgut [20]; rows C and D, cell death genes expressed in the larval salivary gland [37]; rows E and F, genes that change expression in response to starvation or a sugar diet [45]; rows G and H, genes that change expression in response to either paraquot, tunicamycin, or H2O2 [43]; and rows I and J, genes that change expression in response to bacterial insult [44]. Each gene set is divided into upregulated or downregulated genes as represented by the arrows, with the number of genes in each dataset represented by '(n =)'. The first number in each cell represents the number of overlapping genes between the two datasets being compared. The numbers within the parentheses in each cell represent a p value based on the χ2 test that accounts for the differences between the observed and expected numbers. Correlations discussed in the text are marked with an asterisk (all those showing a p value ≤ E-10).
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Genome Biology

ISSN: 1474-760X

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