Protein-protein interactions of the hyperthermophilic archaeon Pyrococcus horikoshiiOT3

Table 1 The selected self-interaction proteins

	Annotated or functional predicted proteins		Hypothetical proteins
	Gene ID	Function	Gene ID
Ortholog to eubacteria, eukaryote and archaea proteins	PH0125*	5'-methylthioadenosine phosphorylase	PH1904
	PH0413*	Glucose-1-phosphate thymidylyltransferase
	PH0540*	S-adenosyl-L-homocysteine hydrolase
	PH0655*	Threonine-3-dehydrogenase
	PH1355	SNZ like protein
	PH1589*	Deoxycytidylate deaminase
	PH1884*	Triosephosphate isomerase
Ortholog to eubacteria and archaea proteins	PH0385	MorR-like ATPase	PH0008
	PH0596*	Pyrrolidone-carboxylate peptidase	PH1305
	PH0634*	6-pyruvoyl-tetrahydropterin synthase	PH1503
	PH0762*	Probable thymidylate synthase	PH1950
	PH0776	Methanol dehalogenase regulatory protein	PH0519
	PH0986^†	Lactam utilization protein	PH1474
	PH1153*	Putative acetylornithine deacetylase	PH1918
	PH1408	Putative uridylate kinase
	PH1692*	Transcriptional regulator (AsnC-like protein)
	PH1821*	Frv operon protein, endoglucanase
	PHS023*	Regulatory protein AsnC
Ortholog to eukaryote and archaea proteins	PH0119*	DNA repair protein (RadA/Rad51)	PH1257
	PHS042*	Small nucleoprotein
Archaea-specific proteins	PHS053*	Archaea-specific DNA-binding protein AlbA	PH0073
			PH0130^†
			PH0197
			PH0250^†
			PH0406
			PH0795
			PH1025
			PH1120
			PH1528^†
			PH1895^†
			PHS017^†
			PH0127
			PH0187
			PH0223
			PH0346^†
			PH0690
			PH0860^†
			PH1191^†
			PH1126^†
			PH1850^†
			PH1931

The gene identity code (ID) refers to that of Database of Genomes Analyzed in NITE (DOGAN) [26] entries for P. horikoshii OT3 [26]. Ortholog classification was performed using the Sequence Similarity Database (SSDB) [46] in the Kyoto Encyclopedia of Genes and Genomes (KEGG) [48,49]. *The proteins were reported to form a homo-oligomer in P. horikoshii OT3 or orthologous proteins (interlogs of self-interaction). ^†Proteins unique to Pyrococcus without orthologs in another archaea species.

ISSN: 1474-760X