A computational investigation of kinetoplastid trans-splicing

Table 1 Classification of sequences by linear discriminant analysis (LDA)

	Known trans-splicing regions	Known coding regions
Predicted trans-splicing region	True positive	False positive
	20	0.9
	(14-24)	(0-3)
Predicted coding region	False negative	True negative
	0.7	18.5
	(0-2)	(10-31)
	Sensitivity: 0.97	Specificity: 0.96
	(0.91-1.00)	(0.88-1.00)
	Accuracy: 0.96
	(0.90-1.00)

The overall performance of the LDA method after tenfold cross-validation using 214 known trans-splicing regions and 198 coding regions is shown here. The average across all ten testing sets is reported, with the range of values indicated in parentheses for each class of sequence. Each test dataset had on average 20.7 known trans-splicing regions and 19.4 known coding regions.

ISSN: 1474-760X