Skip to main content
Figure 1 | Genome Biology

Figure 1

From: Transcriptome analysis of antigenic variation in Plasmodium falciparum - var silencing is not dependent on antisense RNA

Figure 1

A dominant var gene is upregulated in CSA binding parasites. Plots of log2 ratio of expression (M) against average log intensity (A) for ring, trophozoite and schizont stages for CSA versus CD36 panned parasites. Only statistically differential data giving a Bonferroni corrected p value (alpha = 0.05) have been displayed. This graph excludes probes corresponding to antisense transcripts and oligos to 3D7 var genes (whose orthologs in FCR3 diverge in sequence). Biological replicates were pooled. The plots reveal a single dominant var transcript (var2csa-marked in orange) that is much more abundant in CSA than in CD36-panned parasites at all life stages. Green dots represent all other oligos corresponding to FCR3 var genes. Several var genes are over-represented in CD36 as compared with CSA-panned parasites. Both log2 ratios of expression and apparent average intensities for var genes decrease through the life cycle.

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us