Methylation by DRM1/2 and AGO4 is associated with the size of their targets. (a) The loss of methylation for each locus is calculated from the reduction seen in drm1/2 and ago4 when measured by bisulfite sequencing (drm1/2: correlation coefficient r = 0.82, p < 0.003; ago4: r = 0.90, p = 0.0002). The fraction methylated is the ratio of mutant to wild-type percentages listed in Table 3. Regression lines are shown for clarity. (b) A similar comparison of CMT3 and KYP reveals no significant associations (cmt3: r = -0.48, p = 0.2; kyp: r = -0.32, p = 0.5), so no regression lines are shown. The comparisons include data reported in this study supplemented with previously published data for other loci [11,12].