Inferring protein domain interactions from databases of interacting proteins

Table 3 Potential domain interactions between Ran homologs and Ran-binding proteins

Several domain interactions are possible in the interactions of yeast and worm Ran signal-transducing proteins with some Ran-binding proteins. Of these possible domain interactions, DPEA predicts the interaction (E = 3.6) of a Pfam-B domain [Pfam:PB001470] found at the C-termini of Ran homologs but not in other Ras family members [Pfam:PF00071] with Ran-binding domains [Pfam:PF00638, Ran_BP1]. Structural [43] and biochemical [44] studies confirm this interaction. We conclude that DPEA identified, from among several possibilities, an important domain interaction for the interaction of Ran homologs with a subset of Ran-binding proteins.

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