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Table 1 Distribution of homologs of the metazoan NPC and NPCa proteins across different lineages of eukaryotes and prokaryotes

From: The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure

Localization/Function

Metazoa

Fungi

Microsporidia

Green plants

Rhodophytes

Conosa

Diplomonads

Diatoms

Kineto-plastids

Alveolates

Archaea

Bacteria

NPC proteins [5,6,39,40]

Integral membrane

Gp210 (Pom210)

Pom152

Pom152

         
 

POM121

Pom34

          
  

Ndc1

          

Spokes

Nup93

*** Nic96p

***

***

        
 

Nup205

*** Nup192p

 

***

 

***

      
 

Nup188

*** Nup188p

 

***

        

Central transporter

Nup62

*** Nsp1p

 

***

 

***

      
 

Nup58a

** Nup49p

 

**

        
 

Nup54

*** Nup57p

 

***

        
 

Nup45a

** Nup49p

 

**

        

Nuclear side

Nup133

*** Nup133p

 

***

        
 

Nup96b

*** C-nup145pc

 

***

        
 

Nup107

*** Nup84p

 

***

        
 

Nup160

*** Nup120p

 

***

        
 

Nup37 [5]

**

 

**

  

***

   

*

***

 

Nup43

***

 

***

       

***

 

Nup75

*** Nup85p

***

***

 

***

   

***

  
 

Seh1 (sec13L)

*** Seh1p

***

***

 

***

  

***

***

*

***

 

Sec13R

*** Sec13p

***

***

***

***

*

*

**

***

*

**

Cytoplasmic fibrils

Nup35 (MP-44)

*** Nup59p Nup53p

 

***

  

***

     
 

Nup214 (Cain) (Can)

*** Nup159p

          
 

Nup88

*** Nup82p

 

***

 

***

   

***

  
 

Ran-Gap1

***

***

***

 

*

  

*

**

  
 

Nup358 (Ranbp2) (Rbp2)

**

 

**

 

*

      
 

Ubc9 (Ube2I)

*** Ubc9p

***

***

 

***

***

 

***

***

  

Nucleoplamic fibrils (basket)

Nup98

*** N-Nup145pc Nup116p Nup100pd

 

***

**

***

      
 

Rae1 (gle2)

*** Gle2p

***

***

***

***

 

***

***

***

*

***

 

Tpr

*** Mlp1p Mlp2p

 

***

        
 

Nup153

Nup1p

          
 

Nup50 (Npap60L)

Nup2p

 

***

        

Other

Nup36d

*** Nup100pd

***

         
 

Cg1 (Nlp1)

*** Nup42p (Rip1p)

 

***

        
 

Nup155

*** Nup170p Nup157p

***

***

***

 

***

***

 

***

  
 

Aladin [5]

***

 

***

***

***

     

***

NPCa proteins

Nuclear periphery [5]

p30

  

***

       

***

SUMO-1 protease [55,56]

Senp2

***

 

***

    

***

***

  

Nuclear mRNA export factor [57]

Tap

***

   

***

      

Nuclear export [58]

Rcc1

***

  

***

***

 

*

*

   

Nuclear Import

Importin(s)

***

 

***

***

***

 

***

***

***

***

***

Nuclear mRNA export [59]

Ddx19 Dbp5

*** Dbp5

***

***

***

***

 

*

*

***

 

***

Nuclear mRNA export [60]

Gle1

*** Gle1

  

***

  

***

    

Nuclear export [10]

Ranbp1

***

***

***

***

***

 

*

***

***

  

Nuclear import Importin 7 [61]

Ranbp7

***

 

***

***

***

   

***

  

Nuclear import Importin 8 [61]

Ranbp8

***

 

***

***

***

   

***

  

[62]

Mad1 (Mad1L) (Mad1a)

*** Mad1

 

***

*

       

[62]

Mad2 (Mad2L1) (Mad2a)

*** Mad2

 

***

***

***

***

***

 

***

  

Nuclear export [10]

Crm1

***

 

***

        

Nuclear mRNA export [63]

HnRNPF

  

**

        

Nuclear mRNA export [63]

HnRNPH

  

**

        

Nuclear mRNA export [63]

HnRNPM

***

 

***

     

***

  

Nuclear export [58,64]

Ran

***

***

***

***

***

***

***

***

***

  

Homolog of unc-84 in C. elegans [42]

Unc-84B

***

 

***

  

***

  

***

  

Inner nuclear membrane protein [65]

Ha95

          

**

Inner nuclear membrane protein [42]

Luma

          

***

Inner nuclear membrane protein [66]

Emerin

           

Inner nuclear membrane protein [42,67]

Nurim

          

***

Inner nuclear membrane protein [42,65]

Man1

   

*

*

 

***

*

*

  

Lamin B receptor [65]

Lbr

***

  

***

***

 

*

*

  

***

Peripheral protein of the inner nuclear membrane [68]

Otefin

           

Ring finger binding protein [65]

Rfbp

   

*

***

***

 

***

***

 

**

Lamina [65]

LaminaA/C

***

          

Lamina [65]

LaminaB1

           

Lamina [65]

LaminaB2

           

Protein co-localized with the nuclear lamina [69]

Narf

   

***

***

***

*

*

***

 

***

Lamina associated polypeptid [65,70]

Lap1

           

Lamina associated polypeptide [65,71]

Lap2

           
  1. aNup58 and Nup45 proteins are generated by alternative splicing of the nup58/nup45 gene mRNA. bNup96 and Nup98 are cleaved from a 186 kDa precursor protein. cN-Nup145p and C-Nup145p are cleaved from the Nup145p precursor protein. dNup36 showed 96.8% identity with the carboxy-terminal region of Nup100p. ***, indicates proteins for which the homology with metazoan proteins seems indisputable and allows good alignments; **, indicates proteins with a likely homology; *, indicates proteins for which a putative homology has been detected by BLAST, but for which no alignment was possible; italic font corresponds to proteins for which no sequence homology was detected but for which structural analyses revealed similar positions within the nuclear pore complex (NPC); underlined font indicates sequences identified using the reconstruction of ancestral sequences.
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Genome Biology

ISSN: 1474-760X

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