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Table 1 Character of residues in the conserved positions of the ligand-binding box

From: Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

Ratio of aromatic residues Overall aromaticity
Position* R104(D) L112(D) W143(C) T144(C) Y185(C) Y192(C)  
Bacteria 0.2 0.53 0.2 0.0 0.6 0.53 2.1
Animals 0.14 0.22 0.82 0.0 0.54 0.89 2.6
  1. *The positions correspond to the D and C chains of ACHB (PDB: 1UV6)