A phylogenetic tree of proteins containing the ART-LGIC domain with relevant domain architectures and gene neighborhoods. Bacterial branches are colored blue and animal branches magenta. Nodes with maximum-likelihood RELL bootstrap support of more than 70% are shown as yellow circles. Selected gene neighborhoods that provide contextual functional information are shown as box arrows. The globular domains in the domain architectures are drawn approximately to scale. LBD, the ligand-binding domain of the ART-LGIC domain. Species abbreviations are as in Figure 1.