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Table 5 Comparison of known essential human nutrients with corresponding biosynthetic pathways in MetaCyc and in HumanCyc

From: Computational prediction of human metabolic pathways from the complete human genome

Essential nutrient in humans Biosynthetic pathway in MetaCyc? Biosynthetic pathway inferred in humans?
Amino acids   
Arginine Y N
Histidine Y N
Isoleucine Y N
Leucine Y N
Lysine Y N
Methionine Y N
Phenylalanine Y N
Threonine Y N
Valine Y N
Vitamins   
Ascorbic acid (Vitamin C) Y N
Biotin (Vitamin H) Y N
Folic acid (Vitamin M) Y N
Niacin (Vitamin B3) N N
Pantothenic acid Y Y
Pyridoxine (Vitamin B6) N N
Riboflavin (Vitamin B2) Y N
Thiamine (Vitamin B1) Y N
Cobalamin (Vitamin B12) Y N
Retinol (Vitamin A) N N
Vitamin D N N
Tocopherol (Vitamin E) N N
Vitamin K N N
  1. Note that a pathway cannot be predicted in HumanCyc if it does not exist in MetaCyc.