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Figure 4 | Genome Biology

Figure 4

From: Global expression changes resulting from loss of telomeric DNA in fission yeast

Figure 4

Gene-expression profiles of cells experiencing senescence and survivors. (a) Graph of expression for all genes showing fold-change relative to wild type for each day of the growth curve. Each gene is represented as a line with discontinuities resulting from missing data. For clarity, three genes (missing from the genome, see text) with expression reduced tenfold or more are not shown: trt1+, SPAC2E1P3.04 and SPAC2E1P3.05c. (b) Hierarchical clustering of the 123 genes whose expression changed by twofold or more relative to wild-type in two or more days of the growth curve (see text for details). Samples d1-d15 are days of the growth curve. Each column represents expression of all 123 genes for a unique condition. Each row represents the expression pattern of a single gene throughout all conditions. Genes shown in red had upregulated expression and those in green had downregulated expression. Values of fold-change less than 1.2 are in black, and gray areas indicate missing data. Brackets labeled with letters a-b along the right-hand side denote sets of genes with similar expression patterns for one or more conditions. Band 'a' consists of genes with downregulated expression: SPAC2E1P3.05c, SPAC2E1P3.04, trt1+ and SPBC359.02; and band 'b' represents the second wave of gene expression in the growth curve. The wild-type sample was an average of biological replicates WT 3 and WT 5. (c) Dendrogram of the experimental conditions and strains shown in (b). Experiments were hierarchically clustered on the basis of the similarity of expression ratios of the 123 genes shown in (b).

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