Skip to main content

Table 2 Selected interaction partners of MAP2/Tau family proteins

From: The MAP2/Tau family of microtubule-associated proteins

Family member Interacting protein Proposed function of the interaction Reference
MAP2 Microtubules Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity, neurite initiation [77]
  F-actin Modulation of neurite initiation [16]
  Regulatory subunit RII of PKA Localization of PKA to hippocampal dendrites; facilitation of cAMP-responsive element binding protein (CREB) phosphorylation; modulation of neurite initiation [44]
  Tyrosine kinase Src Signal transduction and integration [78]
  Adapter protein Grb2 Signal transduction and integration [78]
  Tyrosine kinase Fyn Signal transduction and integration [79]
  Neurofilaments Crossbridges between microtubules and neurofilaments [80]
  Class C L-type calcium channels Linking PKA to channels [81]
  MAP2-RNA transacting proteins MARTA1 and MARTA2 Interaction with MAP2 mRNA: targets MAP2 mRNA to dendrites [82]
Tau Microtubules Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity [83]
  Fyn Modulation of microtubule organization; pathogenesis of Alzheimer's disease [84]
  Src Unknown [84]
  Presenilin 1 Links Tau to glycogen synthase kinase 3β; pathogenesis of Alzheimer's disease [85]
  Apolipoprotein E Regulation of Tau metabolism; pathogenesis of Alzheimer's disease [86]
  Calmodulin Regulation of microtubule assembly [87]
  Calmodulin-related protein S100b Regulation of Tau phosphorylation by protein kinase C [87]
MAP4 Microtubules Stabilization of microtubules; inhibition of depolymerization (catastrophes) [49]
  Cyclin B Links p34cdc2 kinase to microtubules; regulation of M-phase microtubule dynamics [51]