Table 2 Selected interaction partners of MAP2/Tau family proteins
From: The MAP2/Tau family of microtubule-associated proteins
| Family member | Interacting protein | Proposed function of the interaction | Reference |
|---|---|---|---|
| MAP2 | Microtubules | Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity, neurite initiation | [77] |
| F-actin | Modulation of neurite initiation | [16] | |
| Regulatory subunit RII of PKA | Localization of PKA to hippocampal dendrites; facilitation of cAMP-responsive element binding protein (CREB) phosphorylation; modulation of neurite initiation | [44] | |
| Tyrosine kinase Src | Signal transduction and integration | [78] | |
| Adapter protein Grb2 | Signal transduction and integration | [78] | |
| Tyrosine kinase Fyn | Signal transduction and integration | [79] | |
| Neurofilaments | Crossbridges between microtubules and neurofilaments | [80] | |
| Class C L-type calcium channels | Linking PKA to channels | [81] | |
| MAP2-RNA transacting proteins MARTA1 and MARTA2 | Interaction with MAP2 mRNA: targets MAP2 mRNA to dendrites | [82] | |
| Tau | Microtubules | Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity | [83] |
| Fyn | Modulation of microtubule organization; pathogenesis of Alzheimer's disease | [84] | |
| Src | Unknown | [84] | |
| Presenilin 1 | Links Tau to glycogen synthase kinase 3β; pathogenesis of Alzheimer's disease | [85] | |
| Apolipoprotein E | Regulation of Tau metabolism; pathogenesis of Alzheimer's disease | [86] | |
| Calmodulin | Regulation of microtubule assembly | [87] | |
| Calmodulin-related protein S100b | Regulation of Tau phosphorylation by protein kinase C | [87] | |
| MAP4 | Microtubules | Stabilization of microtubules; inhibition of depolymerization (catastrophes) | [49] |
| Cyclin B | Links p34cdc2 kinase to microtubules; regulation of M-phase microtubule dynamics | [51] |