Table 2 Selected interaction partners of MAP2/Tau family proteins

MAP2

Microtubules

Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity, neurite initiation

[77]

F-actin

Modulation of neurite initiation

[16]

Regulatory subunit RII of PKA

Localization of PKA to hippocampal dendrites; facilitation of cAMP-responsive element binding protein (CREB) phosphorylation; modulation of neurite initiation

[44]

Tyrosine kinase Src

Signal transduction and integration

[78]

Adapter protein Grb2

Signal transduction and integration

[78]

Tyrosine kinase Fyn

Signal transduction and integration

[79]

Neurofilaments

Crossbridges between microtubules and neurofilaments

[80]

Class C L-type calcium channels

Linking PKA to channels

[81]

MAP2-RNA transacting proteins MARTA1 and MARTA2

Interaction with MAP2 mRNA: targets MAP2 mRNA to dendrites

[82]

Tau

Microtubules

Stabilization of microtubules; inhibition of depolymerization (catastrophes); increase in microtubule rigidity

[83]

Fyn

Modulation of microtubule organization; pathogenesis of Alzheimer's disease

[84]

Src

Unknown

[84]

Presenilin 1

Links Tau to glycogen synthase kinase 3β; pathogenesis of Alzheimer's disease

[85]

Apolipoprotein E

Regulation of Tau metabolism; pathogenesis of Alzheimer's disease

[86]

Calmodulin

Regulation of microtubule assembly

[87]

Calmodulin-related protein S100b

Regulation of Tau phosphorylation by protein kinase C

[87]

MAP4

Microtubules

Stabilization of microtubules; inhibition of depolymerization (catastrophes)

[49]

Cyclin B

Links p34^cdc2 kinase to microtubules; regulation of M-phase microtubule dynamics

[51]