The domain organization of MAP2/Tau family proteins. Selected isoforms of the human members of the family are shown, as well as the nematode homolog PTL-1. All family members have alternative splice forms with varying numbers of carboxy-terminal microtubule-binding repeats and amino-terminal projection domains of varying lengths. PKA (RII) indicates a domain interacting with the RII subunit of protein kinase A. Repeats that are not present in all major isoforms are shown lighter.