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Table 11 Major genes of the cAMP, cGMP and calcium signaling pathways

From: Function-informed transcriptome analysis of Drosophila renal tubule

Function Gene name Signal Enrichment Comments
cAMP     
Adenylate cyclase rutabage 121 ± 12 1.4 ± .2  
  Ac78C 44 ± 5 7.2 ± 1.6  
  Ac13E 106 ± 4 4.1 ± 0.5  
Protein kinase A Pka-C3 88 ± 9 1.7 ± 0.2 Catalytic subunit
  Pka-R1 183 ± 13 1.2 ± 0.1 Regulatory subunit
PDE dunce 147 ± 6 3.9 ± 0.6 cAMP-specific
Calcium     
CamKinase Caki 112 ± 10 1.7 ± 0.2  
Phospholipase C Small wing 46 ± 6 1.1 ± 0.2  
  Plc21C 58 ± 5 1.1 ± 0.1  
Calcium release channels Itp-r83A 11 ± 2 1.2 ± 0.2 InsP3 receptor
Calmodulin Calmodulin 1,019 ± 57 0.9 ± 0.06  
Protein kinase C Pkc98E 217 ± 15 1.7 ± 0.2  
cGMP     
Guanylate cyclase CG14885 13 ± 3 6 ± 2.5 Probably soluble beta subunit
  Gyc76C 410 ± 23 2.9 ± 0.4 Membrane form
  CG4224 23 ± 4 0.8 ± 0.2 Membrane form
  CG9873 137 ± 5 2.0 ± 0.7 Membrane form
  Gycbeta100B 20 ± 4 0.8 ± 0.1 Cytoplasmic, beta subunit
  CG5719 9 ± 3 3.5 ± 1.4 Membrane form
PDE CG10231 182 ± 4 3.7 ± 0.6 cGMP-specific, PDE11-like
Protein kinase G foraging 91 ± 2 0.3 ± 0.01  
  Pkg21D 448 ± 20 15.7 ± 2.3  
Serine/threonine protein phosphatases
  Cg17746 258 ± 32 4.3 ± 0.6 PPA-2C like
  puckered 228 ± 11 2.5 ± 0.2 Multifunctional
  twins 209 ± 11 2.0 ± 0.1 PPA-2A like
  Pp2A-29B 738 ± 28 1.9 ± 0.2 PPA-2A like
  Microtubule star 997 ± 46 1.3 ± 0.1 PPA-2A like
  Pp1-87B 318 ± 17 1.1 ± 0 PPA-1 like
  Pp1alpha-96A 332 ± 8 1.1 ± 0 PPA-1 like
Accessory proteins, associated with anchoring, cellular localization or modulation of signaling
  Akap550 136 ± 6 2 ± 0.3 A-kinase anchor protein
  AKAP200 414 ± 30 0.35 ± 0.02  
  14-3-3-zeta 1,789 ± 42 2.6 ± 0.2 Diacylglycerol-activated PKC inhibitor
  CG32812 42 ± 4 2.7 ± 0.4 Calcineurin
  Rack1 6,463 ± 105 1.3 ± 0 Receptor for activated C-kinase