From: The cyclooxygenases
Property | COX-1 | COX-2 |
---|---|---|
Chromosomal location of gene | 9q32-q33.3 | 1q25.2-25.3 |
Copy number of gene | Single | Single |
Gene size | About 22 kb | About 8 kb |
Number of exons | 11 | 10 |
Number of introns | 10 | 9 |
Length of primary mRNA | 2.8 kb | 4.5 kb |
Length of differentially polyadenylated variants | 4.5 kb, 5.2 kb | 4.0 kb, 2.8 kb |
Lengths of splice variants | See [13,34] | See [13,34] |
Length of coding region | 1,797 nucleotides | 1,812 nucleotides |
Putative transcription regulatory elements found in: | Â | Â |
   promoter | TATA-less | TATA box |
   5' upstream region* | AP-2, GATA-1, NF-IL6, NFκB, PEA-3, SP-1, SSRE | AP-2, C/EBP, CRE, GATA-1, GRE, NF-IL6, NFκB, PEA-3, SP-1 |
   3' untranslated region |  | AUUUA repeats |
Expression | Constitutive | Inducible (by cytokines, growth factors and so on [10,35]) |
Length of protein (with signal peptide) | 599 amino acids | 604 amino acids |
Length of mature protein (without signal peptide) | 576 amino acids | 581 amino acids |
Number of glycosylation sites | 3 | 3-4 (variable) |
Cofactors | Heme | Heme |
Substrates | Arachidonic acid | Arachidonic acid and others |
Quaternary structure | Homodimer | Homodimer |
Subcellular location | Endoplasmic reticulum | Endoplasmic reticulum and nuclear envelope |