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Table 1 The 15 characterized NAHR breakpoints within AZFa-HERVs

From: Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFadeletion hotspots

Study

Type of rearrangement

Independent rearrangements

Breakpoint in ID1

Breakpoint in ID2

[9]

Deletion

1

0

1

[9]

Gene conversion*

2

2

2

[14]

Deletion

6

4

2

[15]

Deletion

2

1

1

[25]

Duplication

2

2

0

  

Total

9

6

  1. *These gene conversion events appear to be associated with a double-crossover mechanism, and so each gene conversion event is associated with two breakpoints (see Figure 10b).