System-based proteomic analysis of the interferon response in human liver cells

Table 2 Partial list of cis-DNA elements of IFN-induced proteins

Gene	Position	Strand	Sequence	Binding site
ACACA	-1847	Rev	GTTTCTTTTTC	ISRE
	-3800	Rev	AGTTTCGGATTC	IRF-7
B2M	-167		GAAAAGGAAAC	ISRE
	-161		GAAACTGAAAAC	IRF-7
	-2738	Rev	GCTTTCATTTTC	ISRE/IRF-7
G1P2	-316		GAAAATGAAAC	ISRE/IRF-7
	-114		GAAAGGGAAACC	ISRE/IRF-3
	-108		GAAACCGAAAC(T)	ISRE/IRF-3/IRF-7
GBP1	-128	Rev	ACTTTCAGTTTC	IRF-7
GSA7	185	Rev	AATTTCATTTTC	IRF-7
IFIT1	-143	Rev	(A)GTTTCACTTTC	ISRE/IRF-7
	-405		GAAACTGAAAAT	IRF-7
	-2096	Rev	AATTTCATTTTC	IRF-7
IFIT4	-173	Rev	(G)GTTTCATTTTC	ISRE/IRF-7
	-139	Rev	(A)GTTTCACTTTC	ISRE/IRF-7
ISG20	-86		GAAAGGAAAC	ISRE
	140		GAAACTGAAAC	ISRE
KIAA0186	-609		GAAATGGAAAGC	ISRE
KIAA1276	-1048		GAATCCGAAAAC	ISRE
LAMB1	-3940		GAAAGGAAAGC	ISRE
LOC151636	-94		GAAACTGAAAC(T)	ISRE/IRF-7
MX1	-101	Rev	GTTTCGTTTC	ISRE
	-56	Rev	GTTTCATTTC	ISRE
NMI	-78		GAAAGTGAAATT	IRF-7
NUDT2	-746		TTCCCGGAA	GAS
	-2530	Rev	GTTTCCTTTC	ISRE
OAS3	-170		GAAACGAAAC	ISRE
	-165		GAAACTGAAAGC	ISRE/IRF-7
	-34		GAAAACGAAACC	ISRE/IRF-7
PCMT1	-1370		GAATTTGAAAAT	IRF-7
PRKR	-3617		GAAAGGAAAC	ISRE
	-374	Rev	GTTTCCTTTC	ISRE
RPLP0	-1089		GAAACGGAAAGT	IRF-3
STAT1	39	Rev	(A)GTTTCGCTTTC	ISRE/IRF-3/IRF-7
UBE2L6	-1813		TTCCGGGAA	GAS

44% of promoter sequences have at least one of the following consensus sequences: GAS, TTCCSGGAA; ISRE, GAAA(N){1,2}GAAA(G){0,1}C [16]; IRF-3, GAAASSGAAANY; IRF-7, GAAWNYGAAANY.

ISSN: 1474-760X