Phylogenetic class | bHLH family | Example mammalian protein | Function |
---|---|---|---|
A | MyoD | Myf4 | Myogenic: initiates myogenic programme in many cell types |
 | NeuroD | Neurogenic differentiation factor NDF2 | Neurogenic: involved in terminal neurone differentiation |
 | SCL | Tal1 | Hematopoietic: essential for primitive hematopoiesis and invokes enhanced proliferation and differentiation during erythroid development |
 | Hand | dHand | Cardiogenic: regulates the morphogenetic events of asymmetric heart development |
B | Myc | c-Myc | Cell proliferation and differentiation; oncogenic |
 | Mad | Mad1 | Regulation of cell proliferation |
 | SREBP | SREBP-2 | Cholesterol metabolism |
C | Sim | Single-minded 1 (Sim1) | Neurogenic: regulation of midline cell lineage in the central nervous system |
D | Emc | Id1 | Myogenic and neurogenic: negative inhibition of DNA binding |
E | Hairy | Hes1 | Neurogenic: restricts differentiation of neurons from neural precursor cells |
F | Coe | Early B-cell factor (EBF1) | Hematopoietic: essential for B-cell development |