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Table 2 The bHLH protein structures available in the Protein Data Bank (PDB)

From: An overview of the basic helix-loop-helix proteins

PDB code

Protein Chains

Protein name

Species

Group

SCOP superfamily

CATH homologous superfamily

CATH sequence family

1mdy*

ABCD

MyoD bHLH

Mouse

A

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.1

1an4

AB

USF bHLH

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1an2

AC

Max bHLHZ

Mouse

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1hlo

AB

Max bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1nlw*

BE

Max bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1nkp*

BE

Max bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1nkp*

AD

Myc prot-oncogene bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.2

1am9*

ABCD

SREBP-1a bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.3

1ukl

CDEF

SREBP-2 HLHZ

Human

B

NC

NC

NC

1a0a*

AB

Pho4 bHLH

S. cerevisiae

B

Helix-loop-helix DNA-binding domain

MyoD basic-helix-loop-helix domain, subunit B

4.10.280.10.4

1nlw*

AD

Mad bHLHZ

Human

B

Helix-loop-helix DNA-binding domain

NC

NC

  1. The PDB codes and protein names for nine bHLH proteins deposited in the PDB are shown with their superfamily names from the CATH [23] and SCOP [24] classifications and their sequence family numbers from CATH. Max has more than one structure solved, including two complexes (1nkp, Max-Myc and 1nlw, Max-Mad). *Structures shown in Figure 1; NC, the protein is not yet included in the CATH or SCOP protein structure classifications. SREBP, steroid response element binding protein. 'Protein chains' indicates the chain identification letter assigned to individual subunits in the PDB files.