Phylogenetic group | Description | Classification according to Murre et al. [12] | Examples of classified proteins (family names) |
---|---|---|---|
A | Bind to CAGCTG or CACCTG | I, II | MyoD, Twist, Net |
B | Bind to CACGTG or CATGTTG | III, IV | Mad, Max, Myc |
C | Bind to ACGTG or GCGTG. Contain a PAS domain | Â | Single-minded, aryl hydrocarbon receptor nuclear translocator (Arnt), hypoxia-inducible factor (HIF), Clock |
D | Lack a basic domain and hence do not bind DNA but form protein-protein dimers that function as antagonists of group A proteins | V | ID |
E | Bind preferentially to N-box sequences CACGCG or CACGAG. Contain an orange domain and a WRPW peptide | VI | Hairy |
F | Contain an additional COE domain, involved in dimerization and DNA binding | Â | Coe (Col/Olf-1/EBF) |