Detailed view of the main clusters in the network linking annotated protein complexes and high-throughput regulons. The network was built considering all the associations with E-value ≤ 0.1; regulons and complexes are denoted and depicted as described in the legend of Figure 1. (a) Cluster of associations involving seven of the eight components of the nucleosomal protein complex. Unlike in the equivalent cluster of Figure 1a, here only two distinct groups of, respectively, two and six genes belonging to three rather large regulons (respectively, Met4 and Hir1-2) map into this complex. Note that here Hir1-2 comprises a much larger group of genes than in the annotated regulons. (b) Cluster of the respiratory chain complexes. It comprises three complexes: the F0-F1-ATP-synthase complex, and the cytochrome bc1- and cytochrome c oxidase complexes. Twenty-five genes of the Hap4 regulon, and four and five genes of the Hap3 and Hap2 regulons, respectively, map into these complexes. As noted in the text, the Hap4 transcription factor is known as a respiratory-chain activator that does not bind DNA but fosters DNA binding by Hap2 and Hap3 ). The reasons for the more limited overlap between these latter two regulons and components of the respiration complexes are not clear. (c) An interesting cluster where the main node is the large Mbp1 regulon of 112 genes, of which 10 overlap with components of three complexes: the small replication factor A complex (3 genes), the replication complexes (49 genes) and the Cdc28p complexes (10 genes).