Figure 1

Detailed view of the main clusters in the network linking annotated protein complexes and regulons. The network (shown Additional data file 1 (Figure S1)) was built from the multiple links corresponding to associations with E-value ≥ 0.1, identified between the 243 CYGD yeast multiprotein complexes and the 200 annotated regulons (see text). Ellipsoid frames represent complexes, rectangular frame represent regulons, with individual complexes and regulons appearing in different colors in a given cluster. Individual complexes are identified by their name in the CYGD complexes catalog [10] and regulons are denoted by the name of the bound transcription factor. Genes involved in complexes or regulons are enclosed, respectively, in rounded frames or rectangles of the same color as the complex or regulon, and are displayed by their common name. The two digits given in parentheses indicate the number of genes involved in this cluster for the complex or regulon, and the total number of genes in the complex or regulon, respectively. (a) Cluster involving associations between three groups of regulons (Hta1-Hta2, Hir1-2-3, and Spt10-Spt21) and seven of the eight genes of the nucleosomal protein complex. (b) The ribonucleoside diphosphate reductase cluster, involving associations between all four genes of the corresponding complex and four groups of co-regulated genes belonging to six regulons. (c) Cluster involving associations between all the 10 components of the Cdc28p complexes, and seven distinct groups of genes belonging to 11 regulons. Five regulons - Cln3, Sit4, Spt16, Bck2, and Swi4 - map onto the exact same cyclin genes (CLN, CLN2). Two regulons, Swi4, and Mcm1, map also into the glucan synthases and pre-replication complex, respectively.