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Table 1 Classification and chromosomal locations of human sirtuin genes

From: Sirtuins: Sir2-related NAD-dependent protein deacetylases

    

Orthologs

Name

Class

Chromosomal location

OMIM ID

Yeast

Mouse

Sirt1

Ia

10q21.3

604479

Sir2, Hst1

Sir2β

Sirt2

Ib

19q13.2

604480

Hst2

Sir2l2

Sirt3

Ib

11p15.5

604481

Hst2

Sir2l3

Sirt4

II

12q24.31

604482

 

Sirt4

Sirt5

III

6p23

604483

 

Sirt5

Sirt6

IVa

19p13.3

606211

 

Sirt6

Sirt7

IVb

17q25.3

606212

 

Sirt7

  1. Mouse orthologs of human Sirt4-7 have not been characterized but are found in sequence databases. OMIM IDs are from the Online Mendelian Inheritance in Man repository at the National Center for Biotechnology Information (NCBI) [76].