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Table 1 Classification and chromosomal locations of human sirtuin genes

From: Sirtuins: Sir2-related NAD-dependent protein deacetylases

Name Class Chromosomal location OMIM ID Yeast Mouse
Sirt1 Ia 10q21.3 604479 Sir2, Hst1 Sir2β
Sirt2 Ib 19q13.2 604480 Hst2 Sir2l2
Sirt3 Ib 11p15.5 604481 Hst2 Sir2l3
Sirt4 II 12q24.31 604482   Sirt4
Sirt5 III 6p23 604483   Sirt5
Sirt6 IVa 19p13.3 606211   Sirt6
Sirt7 IVb 17q25.3 606212   Sirt7
  1. Mouse orthologs of human Sirt4-7 have not been characterized but are found in sequence databases. OMIM IDs are from the Online Mendelian Inheritance in Man repository at the National Center for Biotechnology Information (NCBI) [76].