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Table 5 Examples of proteins predicted to be myristoylated

From: MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

Protein(s)

Total number in MYRbase

MI in MYRbase (number in cluster)

Taxonomic range

*Disease-resistance proteins

32

25300600 (27) NB-ARC+LRR, 25453543 (5) TIR+NB-ARC+LRR

Plants

†S/T protein phosphatase 2C gamma (1G)

30

2130393 (6)(ptc3), 26450759 (6), 4505999 (5)(1G), 25411959 (4), 22326510 (3), 6728987 (3), 6319415 (3)(ptc2/3), 23172576 (3)Dm,23615237 (2)Pf, 22326564 (2), 7488279 (2), 15239565 (1), 23483487 (1)(1Gpf), 24417194 (1), 25341907 (1), 21626866 (1)(1Gdm), 6319601 (1)(ptc4)

Mammals, insects, fungi, plants, apicomplexa

S/T-kinases (Crk1(cyclin-dependent kinase cdc2-related)-related)

29

22327464 (11), 27817936 (10), 14532736 (4), 25402555 (3), 20805217 (1)

Plants

cGMP-specific 3',5'-cyclic phosphodiesterase 8A, 8B, 9A

23

6166014 (10) 9A, 27479159 (9) 8AB, 21626649 (2) Dm, 2706887 (2)

Mammals, insects

*Thioredoxin

20

15231958 (11), 1388078 (4), 28209505 (2), 28372832 (2), 28372834 (1)

Plants

Putative RING zinc finger proteins (ubiquitin ligases?)

17

20279471 (10), 27500282 (4) Hs Mm, 7292914 (1) Dm, 3874246 (1) Ce, 23488532 (1) Pf

Plants, mammals, insects, apicomplexa

Interferon-inducible GTPase; 47 kDa GTPase IIGP

16

25029534 (16)

Mammals

Mitochondrial import receptor subunit TOM40

16

12230369 (15), 6539563 (1)

Mammals, amphibians, insects, plants

‡Germ cell less GCL

15

21314704 (13), 7304006 (1), 6425507 (1)

Mammals, fish, insects, worms

Inward rectifier potassium channel Kir2.1

13

26336911 (13)

Mammals

Sphingolipid delta 4 desaturase DES1/DES2

12

27717299 (12)

Mammals, insects, worms

ARF GTPase-activating protein (PH, ArfGAP, ankyrin domains)

12

22051029 (12)

Mammals

Naked cuticle 1,2 homolog

12

22028145 (11), 27729789 (1)

Mammals

Protein-L-isoaspartate carboxylmethyltransferase

12

27882417 (10), 27713894 (1), 3133008 (1)

Mammals, amphibians, worms

Cyclin-box carrying protein 1

11

1078903 (11)

Mammals, insects, worms

  1. Amino-terminal peptides of single representatives shown to be myristoylated in *[24] and †[152]. ‡Amino-terminal glycine to alanine mutation prevents nuclear envelope localization [153].