Figure 20

Comparison with a two-fold cut-off. Candidates for differentially-expressed genes defined using adjusted supsmu-based STIs or a threshold for ratios from the (a) mac1, (b) spf1 and (c) cin5 experiments. The dashed horizontal lines with intercepts of -1 and +1 correspond to two-fold changes in log-transformed (base 2) ratio. Red and blue dots denote genes up-regulated and down-regulated, respectively, according to this criterion. Moving away from the zero line, the 95%, 99%, 99.8%, 99.98% and 99.998% adjusted supsmu-based STIs are shown (covered with probability at least 0.9999). Further details about the mac1 genes identified with case index numbers can be found in Table 3 (see also Table 2 for comparison of the adjusted supsmu-based STIs with other procedures).