Table 1 Characterization of the 60 C. elegans ABC proteins
Subfamily | ORF name/CGC name | Chromosome | GenBank accession number | Size (amino acids) | Predicted topology | cDNA if known | RNAi phenotype | |
|---|---|---|---|---|---|---|---|---|
A | Abt | C24F3.5/ Abt-1 | IV | CAA18775 | 1,429 | (6TM-ABC)2 | Â | None |
| Â | Â | C48B4.4/ Ced-7 | III | NP_499115 | 1,704 | (8TM-ABC)2 | Complete | None |
| Â | Â | F12B6.1/ Abt-2 | I | AAB54153 | 1,547 | (6TM-ABC)2 | Partial | None |
| Â | Â | F55G11.9/ Abt-3 | IV | CAB05222 | 1,431 | (8/4TM-ABC)2 | Â | None |
| Â | Â | F56F4.6 | I | AAB54203 | 260 | ABC | Â | None |
| Â | Â | Y39D8C.1/ Abt-4 | V | AAC69223 | 1,802 | (6/8TM-ABC)2 | Partial | None |
| Â | Â | Y53C10A.9/ Abt-5 | I | CAA22142 | 1,564 | (6TM-ABC)2 | Partial | None |
B | Pgp (full molecules) | C05A9.1/ Pgp-5 | X | CAA94202 | 1,283 | (6TM-ABC)2 | Partial | None |
| Â | Â | C34G6.4/ Pgp-2 | I | AAB52482 | 1,265 | (6TM-ABC)2 | Partial | None |
| Â | Â | C47A10.1/ Pgp-9 | V | CAB03973 | 1,294 | (6TM-ABC)2 | Partial | None |
| Â | Â | C54D1.1/ Pgp-10 | X | AAC48149 | 1,283 | (4TM-ABC)2 | Partial | None |
| Â | Â | DH11.3/ Pgp-11 | II | CAA88940 | 1,270 | (6TM-ABC)2 | Partial | None |
| Â | Â | F22E10.1/ Pgp-12 | X | CAA91799 | 1,318 | (6TM-ABC)2 | Partial | None |
| Â | Â | F22E10.2/ Pgp-13 | X | CAA91800 | 1,291 | (6TM-ABC)2 | Â | None |
| Â | Â | F22E10.3/ Pgp-14 | X | CAA91801 | 1,327 | (6TM-ABC)2 | Partial | None |
| Â | Â | F22E10.4/ Pgp-15 | X | CAA91802 | 1,270 | (6TM-ABC)2 | Â | None |
| Â | Â | F42E11.1/ Pgp-4 | X | CAA91463 | 1,266 | (6TM-ABC)2 | Partial | None |
| Â | Â | K08E7.9/ Pgp-1 | IV | CAB01232 | 1,321 | (6TM-ABC)2 | Partial | None |
| Â | Â | T21E8.1/ Pgp-6 | X | CAA94220 | 1,225 | (6TM-ABC)2 | Partial | None |
| Â | Â | T21E8.2/ Pgp-7 | X | CAA94219 | 1,269 | (6TM-ABC)2 | Â | None |
| Â | Â | T21E8.3/ Pgp-8 | X | CAA94203 | 1,243 | (6TM-ABC)2 | Partial | None |
| Â | Â | ZK455.7/ Pgp-3 | X | CAA91467 | 1,268 | (6TM-ABC)2 | Partial | None |
| Â | Haf (half molecules) | C30H6.6/ Haf-1 | IV | CAB02812 | 586 | 4TM-ABC | Partial | None |
| Â | Â | F43E2.4/ Haf-2 | II | AAC71121 | 761 | 8TM-ABC | Partial | None |
| Â | Â | F57A10.3/ Haf-3 | V | CAB09418 | 733 | 6TM-ABC | Partial | None |
| Â | Â | W04C9.1/ Haf-4 | I | AAC68724 | 787 | 8TM-ABC | Complete | Weak embryonic lethality, slow growth |
| Â | Â | W09D6.6/ Haf-5 | III | CAB04947 | 801 | 8TM-ABC | Complete | None |
| Â | Â | Y48G8AL.11/ Haf-6 | I | AAK29911 | 565 | 4TM-NBF | Partial | Â |
| Â | Â | Y50E8A.16/ Haf-7 | V | CAB60586 | 807 | 6TM-ABC | Partial | Â |
| Â | Â | Y57G11C.1/ Haf-8 | IV | CAB16503 | 633 | 4TM-ABC | Â | None |
| Â | Â | ZK484.2/ Haf-9 | I | AAK39394 | 815 | 8TM-ABC | Complete | None |
C | Mrp/Cft | C18C4.2/ Cft-1 | V | AAK52175 | 1247 | (5/6TM-NBF)2 | Partial | None |
| Â | Â | E03G2.2/ Mrp-3 | X | CAA92148 | 1,398 | (6TM-ABC)2 | Partial | None |
| Â | Â | F14F4.3/ Mrp-5 | X | CAB54225 | 1,427 | (6TM-ABC)2 | Partial | Slow growth, Clear |
| Â | Â | F20B6.3/ Mrp-6 | X | AAA82317 | 1,396 | (6TM-ABC)2 | Partial | Egg laying defect |
| Â | Â | F21G4.2/ Mrp-4 | X | CAB02667 | 1,573 | (10/6TM-ABC)2 | Partial | None |
| Â | Â | F57C12.4/ Mrp-2 | X | AAB07022 | 1,525 | (10/6TM-ABC)2 | Complete | None |
| Â | Â | F57C12.5/ Mrp-1 | X | AAD31550 | 1,528 | (12/6TM-ABC)2 | Complete | None |
| Â | Â | Y43F8C.12/ Mrp-7 | V | CAA21622 | 1,119 | (12/2TM-ABC)2 | Partial | Â |
| Â | Â | Y75B8A.26/ Mrp-8 | X | CAA22110 | 1,144 | (4/6TM-ABC)2 | Partial | Â |
D | Â | C44B7.8 | II | AAA68339 | 665 | 4TM-ABC | Partial | Â |
| Â | Â | C44B7.9 | II | AAA68340 | 661 | 4TM-ABC | Partial | None |
| Â | Â | C54G10.3 | V | CAA99810 | 660 | 6TM-ABC | Complete | None |
| Â | Â | T02D1.5 | IV | CAB0590 | 734 | 6TM-ABC | Partial | None |
| Â | Â | T10H9.5 | V | AAC19238 | 598 | 6TM-ABC | Complete | None |
E | Â | Y39E4B.1 | III | CAB54424 | 610 | ABC-ABC | Partial | Embryonic lethality |
F | Â | F18E2.2 | V | CAA99835 | 622 | ABC-ABC | Partial | None |
| Â | Â | F42A10.1 | III | AAA19072 | 712 | ABC-ABC | Partial | None |
| Â | Â | T27E9.7/ GCN20-2 | III | CAB04880 | 622 | ABC-ABC | Complete | None |
G | Â | C05D10.3 | III | AAA20989 | 598 | ABC-4TM | Partial | None |
| Â | Â | C10C6.5 | IV | CAB05682 | 610 | ABC-6TM | Partial | None |
| Â | Â | C16C10.12 | III | CAA86750 | 610 | ABC-4TM | Partial | None |
| Â | Â | F02E11.1 | II | AAB66050 | 658 | ABC-4TM | Partial | None |
| Â | Â | F19B6.4 | IV | CAA93461 | 695 | ABC-6TM | Partial | None |
| Â | Â | T26A5.1 | III | AAC77504 | 608 | ABC-4TM | Partial | None |
| Â | Â | Y42G9A.6 | III | AAF60554 | 684 | ABC-6TM | Partial | None |
| Â | Â | Y47D3A.11 | III | CAB57891 | 547 | ABC-6TM | Partial | None |
| Â | Â | Y49E10.9 | III | CAB11549 | 454 | ABC-4TM | Â | None |
H | Â | C56E6.1 | II | AAA81093 | 1,667 | ABC-12TM | Â | Larval arrest |
| Â | Â | C56E6.5 | II | AAA81094 | 595 | ABC-6TM | Partial | None |