Figure 1

A phylogenetic tree depicting the evolutionary relationships of all known caveolin protein sequences. Note that C. elegans Cav-2 was not included in this analysis because of its low similarity to the mammalian caveolins. GenBank-derived protein sequences were entered into the ClustalW program to generate a phylogenetic tree using the neighbor-joining method. Numbers indicate horizontal branch lengths, which correspond to the estimated evolutionary distances between the protein sequences.