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Table 4 Domain pair enrichment

From: A Drosophila protein-interaction map centered on cell-cycle regulators

AD domain BD domain Domain pairings
Name Exp Rand Fold P Name Exp Rand Fold P Exp Rand Fold P
Cyclin 8 0.5 16 <0.00002 Protein kinase 30 1.7 18 <0.00002 38 0.6 60 <0.00002
F-box 17 1.2 15 <0.00002 Skp1 4 0.1 75 <0.00002 34 0.3 123 <0.00002
F-box 17 1.2 15 <0.00002 Skp1_POZ 4 0.1 65 <0.00002 34 0.3 123 <0.00002
Homeobox 9 2.9 3 0.00080 Protein kinase 30 1.7 18 <0.00002 33 3.7 9 0.00002
Extensin_2 20 11.0 2 0.00316 Protein kinase 30 1.7 18 <0.00002 33 14.0 2 0.01536
Cyclin_C 4 0.3 15 <0.00002 Protein kinase 30 1.7 18 <0.00002 26 0.3 76 <0.00002
Drf_FH1 11 4.3 3 0.00128 Protein kinase 30 1.7 18 <0.00002 19 5.5 3 0.01278
Cyclin 8 0.5 16 <0.00002 RIO1 11 0.3 39 <0.00002 19 0.3 59 <0.00002
Rrm 12 4.3 3 0.00032 Protein kinase 30 1.7 18 <0.00002 18 5.5 3 0.01692
  1. The top 10 domain pairs observed in the interaction list are shown. As expected from interaction profiles (see text), cyclin and protein kinase domains are significantly associated, as are F-box and Skp domains. RIO1 is a recently described kinase domain [62] while the Extensin_2 domain is a proline-rich sequence. Drf_FH1 is the Diaphanous-related formin domain, a low-complexity 12-residue repeat found in proteins involved with cytoskeletal dynamics and the Rho-family GTPases [63], and the Rrm is an RNA-recognition motif. There are also additional associations between protein kinase domains and nucleic acid metabolism domains (see Additional data file 5). These data demonstrate the capacity of relatively small sets of proteins to generate high-confidence domain associations. A complete list of all domains and domain pairs found in the interaction data is in Additional data file 5.