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Table 1 Functions of Jaks

From: The Janus kinases (Jaks)

Gene Phenotype of mouse knockout Cytokines whose signaling requires this Jak
Jak1 Viable but early postnatal lethal owing to neurological deficits; SCID Families of receptor with the shared subunits γc or gp130; IFNs
Jak2 Embryonic lethal owing to a defect of erythropoiesis IL-3; family of receptors with the shared subunit gp130; IFN-γ hormone-like cytokines (EPO, GH, PRL, TPO)
Jak3 SCID, viable and fertile Family of receptor with the shared subunit γc
Tyk2 Viable and fertile; susceptible to parasite infection; resistant to LPS; resistant to collagen-induced arthritis IL-12; LPS
  1. Abbreviations: EPO, erythropoietin; γc, common γ chain; GH, growth hormone; IFN, interferon; IL, interleukin; LPS, bacterial lipopolysaccharide; PRL, prolactin; SCID, severe combined immunodeficiency; TPO, thrombopoietin.