Table 1 Functions of Jaks
From: The Janus kinases (Jaks)
Gene | Phenotype of mouse knockout | Cytokines whose signaling requires this Jak |
|---|---|---|
Jak1 | Viable but early postnatal lethal owing to neurological deficits; SCID | Families of receptor with the shared subunits γc or gp130; IFNs |
Jak2 | Embryonic lethal owing to a defect of erythropoiesis | IL-3; family of receptors with the shared subunit gp130; IFN-γ hormone-like cytokines (EPO, GH, PRL, TPO) |
Jak3 | SCID, viable and fertile | Family of receptor with the shared subunit γc |
Tyk2 | Viable and fertile; susceptible to parasite infection; resistant to LPS; resistant to collagen-induced arthritis | IL-12; LPS |