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Table 3 List of complexes significantly represented in the phylogenetically distinct module cores

From: How biologically relevant are interaction-based modules in protein networks?

Function

Cores (rcc ≥ 5)

Complexes

Cell fate

6 (2)

Actin-associated motor protein, 431

Energy

4 (2)

47, 346, Serine/threonine phosphoprotein phosphatase

Metabolism

9 (3)

521, GGTase II, OT

Cellular transport

2 (2)

Class C Vps, 239, 77, AP-3, AP-2

Cell cycle

7 (4)

Tubulins, CA, AP, 3, OR, SCF-GRR1, SCF-CDC4, RI

Protein fate

10 (5)

Vps, Class C Vps, 71, 77, FT, GGTase I, 168, 651, OT, AP, 23

Transport facilitation

1 (1)

TOM

Cell environment

4 (3)

STE5-MAPK, Kel1p/Kel2p, 521

Protein synthesis

5 (2)

elF3, elF2B, elF2, 340, 339, 613

Cell rescue

3 (3)

No complexes

Signaling

2 (1)

167, 308, 521

Cell organization

9 (6)

272, 5, 71, 289, casein kinase II, 181, 167, Gim

Transcription

9 (6)

154, RM, RP, Ma, Cbf, Mb, 126, NSP1, TF, 178, CPK, 634, 160, CF

  1. Numbers correspond to those complexes found by systematic analysis as described in MIPS [23]. Abbreviations: AP, anaphase-promoting complex; CA, chromatin-assembly complex; Cbf, Cbf1/Met4/Met28; CF, core factor; CPK, cAMP-dependent protein kinase; FT, farnesyltransferase; GGTase I, geranylgeranyltransferase I; GGTase II, geranylgeranyltransferase II; Ma, Met4/Met28/Met32; Mb, Met4/Met28/Met31; OR, origin-recognition complex; OT, oligosaccharyltransferase; RI, replication initiation complex; RM, RNase MRP; RP, RNase P; TF, TFIIIC; TOM, transport across the outer membrane complex; Vps, Vps35/Vps29/Vps2. Here, r cc is the ratio between the number of complex components being part of a core and the total number of complex constituents.