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Table 2 Genes of algal or eubacterial origin in C. parvum

From: Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum

Putative gene name

Accession

Location

Expression

Indel

Putative origin

Putative function

Lactate dehydrogenase*

AAG17668

VII

EST

+

α-proteobacteria

Oxidoreductase

Malate dehydrogenase*

AAP87358

VII

 

+

α-proteobacteria

Oxidoreductase

Thymidine kinase

AAS47699

V

Assay

+

α/γ-proteobacteria

Kinase; nucleotide metabolism

Hypothetical protein A†

EAK88787

II

  

γ-proteobacteria

Unknown

Inosine 5' monophosphate dehydrogenase

AAL83208

VI

Assay

+

ε-proteobacteria

Purine nucleotide biosynthesis

Tryptophan synthetase β chain

EAK87294

V

  

Proteobacteria

Amino acid biosynthesis

1,4-α-glucan branching enzyme

CAD98370

VI

  

Eubacteria

Carbohydrate metabolism

1,4-α-glucan branching enzyme

CAD98416

VI

  

Eubacteria

Carbohydrate metabolism

Acetyltransferase

EAK87438

VIII

  

Eubacteria

Unknown

α-amylase

EAK88222

V

  

Eubacteria

Carbohydrate metabolism

DNA-3-methyladenine glycosylase

EAK89739

VIII

  

Eubacteria

DNA repair

RNA methyltransferase

AY599068

II

  

Eubacteria

RNA processing and modification

Peroxiredoxin

AY599067

IV

  

Eubacteria

Oxidoreductase; antioxidant

Glycerophosphodiester phosphodiesterase

AY599066

IV

  

Eubacteria

Phosphoric ester hydrolase

ATPase of the AAA class

EAK88388

I

  

Eubacteria

Post-translational modification

Alcohol dehydrogenase

EAK89684

VIII

  

Eubacteria

Energy production and conversion

Aminopeptidase N

AAK53986

VIII

  

Eubacteria

Peptide hydrolase

Glutamine synthetase

CAD98273

VI

 

+

Eubacteria

Amino acid biosynthesis

Conserved hypothetical protein B

CAD98502

VI

  

Eubacteria

Unknown

Aspartate-ammonia ligase†

EAK87293

V

EST

 

Eubacteria

Amino acid biosynthesis

Asparaginyl tRNA synthetase†

EAK87485

VIII

  

Eubacteria

Translation

Glutamine cyclotransferase†

EAK88499

I

  

Eubacteria

Amido transferase

Leucine aminopeptidase

EAK88215

V

RT-PCR

+

Cyanobacteria

Hydrolase

Biopteridine transporter (BT-1)

CAD98492

VI

RT-PCR /EST

+

Cyanobacteria

Biopterine transport

Hypothetical protein C† (possible Zn-dependent metalloprotease)

EAK89015

III

  

Archaea

Putative protease

Superoxide dismutase†

AY599065

V

  

Eubacteria /archaea

Oxidoreductase; antioxidant

Glucose-6-phosphate isomerase

EAK88696

II

RT-PCR

+

Algae/plants

Carbohydrate metabolism

Uridine kinase/uracil phosphoribosyltransferase†

AAS47700

VIII

  

Algae/plants

Nucleotide salvage metabolism

Calcium-dependent protein kinases* †

AAS47705

II

RT-PCR

 

Algae/plants

Kinase; cell signal transduction

 

AAS47706

II

    
 

AAS47707

VII

    
  1. *Genes that have been derived from a duplication following transfer; †transferred genes that have less support. GenBank accession numbers are as indicated. Locations are given as chromosome number. The expression status for each gene is indicated by method: EST, RT-PCR or assay. Only 567 EST sequences exist for C. parvum. A + in the indel colum indicates the presence of a shared insertion/deletion between the C. parvum sequence and other sequences from organisms identified in the putative origin column.