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Table 1 Human genes expressed in the liver with alternative 3' splice site exons (A3Es) or alternative 5' splice site exons (A5Es)

From: Variation in alternative splicing across human tissues

Splicing type

Ensembl gene ID

Gene name

Exon numbers

Fold-change above median expression, HG-U95A

Fold-change above median expression, MG-U74A

A5E;A3E

091513

Serotransferrin precursor, TF

8, 9; 4

100

100

A5E;A3E

115414

Fibronectin precursor, FN1

36; 31

10

-

A5E;A3E

117601

Antithrombin-III precursor, SERPINC1

5; 4

100

100

A5E;A3E

136872

Fructose-bisphosphate aldolase, ALDOB

3, 8; 4

100

10

A5E;A3E

140833

Haptoglobin-related protein precursor, HPR

3

100

10

A5E;A3E

151790

Tryptophan 2,3-dioxygenase, TDO2

3, 5; 4

10

100

A5E;A3E

171759

Phenylalanine-4-hydroxylase, PAH

6; 4,10

-

100

A5E

047457

Ceruloplasmin precursor, CP

14, 16

3

-

A5E

055957

Inter-alpha-trypsin inhibitor heavy chain H1 precursor, ITIH1

21

100

10

A5E

111275

Aldehyde dehydrogenase, ALDH2

12

3

3

A5E

132386

Pigment epithelium-derived factor precursor, SERPINF1

4

10

10

A5E

138356

Aldehyde oxidase, AOX1

27, 29

3

3

A5E

138413

Isocitrate dehydrogenase, IDH1

3

1

-

A5E

145692

Betaine-homocysteine S-methyltransferase, BHMT

4

10

100

A5E

160868

Cytochrome P450, CYP3A4

5

10

10

A5E

171766

Glycine amidinotransferase, GATM

8

3

3

A3E

080618

Carboxypeptidase, CBP2

10

-

-

A3E

080824

Heat shock protein HSP 90-alpha, HSPCA

8

-

-

A3E

096087

Glutathione S-transferase, GSTA2

4, 6

10

10

A3E

106927

Protein precursor, AMBP

5, 9

100

100

A3E

110958

Telomerase-binding protein P23, TEBP

5

<1

1

A3E

134240

Hydroxymethylglutaryl-CoA synthase, HMGCS2

8

10

-

A3E

138115

Cytochrome P450, CYP2C8

4

100

10

A3E

145192

Alpha-2-HS-glycoprotein precursor, AHSG

6

100

100

A3E

163631

Serum albumin precursor, ALB

9

100

100

A3E

171557

Fibrinogen gamma chain precursor, FGG

4

100

100

A3E

174156

Glutathione S-transferase, GSTA3

4, 6

10

10

  1. Examples of human AS genes found to exhibit A3E and/or A5E splicing with both isoforms detected in liver-derived ESTs. AS types are listed in the first column, followed by the last six digits of the Ensembl gene number, the gene name and alternative exon numbers. The last two columns list expression levels in human liver and mouse liver tissues, respectively, expressed in terms of the fold-change relative to the median expression level in other tissues (from the DNA microarray data of [43] and [45], respectively).