Figure 3

Androgen-responsive metabolic protein network in LNCaP cells. Specific biochemical pathways represented by the 'energy generation' and 'lipid metabolism' cellular processes, which included the TCA cycle, oxidative phosphorylation, glycolysis, glucogenesis, cholesterol synthesis, glycogen catabolism, fatty acid synthesis and fatty acid oxidation are shown to demonstrate the coordinated coregulated protein expression pattern in response to androgen in LNCaP cells. Black roman font represents proteins not identified using the ICAT reagent method. Black italic font represents proteins that did not change with androgen exposure (d0/d8 ratios > 0.62 and < 1.60). Red represents proteins whose abundance increased with androgen treatment (d0/d8 ratios ≤0.62). Green represents proteins whose abundance decreased following androgen treatment (d0/d8 ratios ≥1.6).