Skip to main content

Table 3 Functional analysis of actual versus random miRNAs

From: MicroRNA targets in Drosophila

  GO molecular function class
  Transcription regulator Apoptosis regulator Cell adhesion molecule Binding Enzyme Transporter Signal transducer Translation regulator Motor Enzyme regulator Structural molecule Chaperone
Actual miRNAs 113 6 10 146 128 35 66 4 6 9 6 1
Random miRNAs (average) 43 1 2 98 88 22 41 2 4 9 7 1
Standard deviation ± 7.5 ± 0.9 ± 1.5 ± 13.3 ± 13.7 ± 4.9 ± 9.7 ± 1.3 ± 2.2 ± 3.9 ± 2.6 ± 1.2
Z-score 9.3 5.9 5.0 3.6 2.9 2.7 2.6 1.4 1.0 0.01 -0.3 -0.3
  1. Integers are number of detected conserved cases in each class. The standard deviation is for 50 experiments. The Z-scores for seven functional classes indicate over-represention for actual miRNA target genes. The thresholds used are S: 100; ΔG: -19 kcal/mol; ID: 70%.